CAJ | 학술논문

目的：观察益气化瘀排浊汤保留灌肠联合复方α－酮酸片治疗慢性肾衰竭的疗效。方法100例慢性肾衰竭患者随机分为两组。在常规治疗的基础上，治疗组采用排浊汤保留灌肠联合复方α－酮酸片口服治疗，而对照组仅用复方α－酮酸片口服治疗，两组均根据病情进行降血压、纠正酸中毒、贫血等对症支持治疗。连续治疗8周后观察临床疗效，并测定血肌酐（Scr）、血尿素氮（BUN）、内生肌酐清除率（Ccr）、血钾、血浆纤维蛋白原（FIB）、血浆黏度、红细胞聚集指数等指标。结果治疗组临床症状显著改善，与对照组比较差异有统计学意义（P ＜0．05）；两组 Scr、BUN 和Ccr 下降，与治疗前比较差异有统计学差异（P ＜0．05）；两组间比较治疗组优于对照组（P ＜0．05）；两组血钾比较无统计学差异（P ＞0．05）。结论益气化瘀排浊汤保留灌肠联合复方α－酮酸片口服治疗慢性肾衰竭患者效果显著，能够改善患者临床症状，保护肾功能，延缓慢性肾脏病的进展。
목적：관찰익기화어배탁탕보류관장연합복방α－동산편치료만성신쇠갈적료효。방법100례만성신쇠갈환자수궤분위량조。재상규치료적기출상，치료조채용배탁탕보류관장연합복방α－동산편구복치료，이대조조부용복방α－동산편구복치료，량조균근거병정진행강혈압、규정산중독、빈혈등대증지지치료。련속치료8주후관찰림상료효，병측정혈기항（Scr）、혈뇨소담（BUN）、내생기항청제솔（Ccr）、혈갑、혈장섬유단백원（FIB）、혈장점도、홍세포취집지수등지표。결과치료조림상증상현저개선，여대조조비교차이유통계학의의（P ＜0．05）；량조 Scr、BUN 화Ccr 하강，여치료전비교차이유통계학차이（P ＜0．05）；량조간비교치료조우우대조조（P ＜0．05）；량조혈갑비교무통계학차이（P ＞0．05）。결론익기화어배탁탕보류관장연합복방α－동산편구복치료만성신쇠갈환자효과현저，능구개선환자림상증상，보호신공능，연완만성신장병적진전。
Abstracts:Objective To observe the clinical effect of Yiqihuayupaizhuo decoction clyster and Alpha ketoanalogue tablets in treatment of chronic renal failure.Methods 100 cases with chronic renal failure CKD3 were randomly divided into two groups.The treatment group was given Yiqihuayu paizhuo decoction clyster and Alpha ketoanalogue tablets,the control group was given Alpha ketoanalogue tablets.After treating for eight weeks,the level of Scr,BUN,Ccr, K +,plasma fibrinogen, plasma viscosity,platelet maximum gathered rate were measured before and after treatment.Results After treatment,the level of Scr,BUN,Ccr, plasma fibrinogen, plasma viscosity,platelet maximum gath-ered rate in treatment group were significantly reduced (P <0.05),and there had significantly differencr between two groups(P <0.05). Conclusion Yiqihuayu paizhuo decoction clyster and Alpha ketoanalogue tablets in treatment of chronic renal failure can particularly reduce the level of Scr, BUN,Ccr, plasma fibrinogen, plasma viscosity and platelet maximum gathered rate, it can improve renal function.