黑龙江医学
黑龍江醫學
흑룡강의학
HEILONGJIANG MEDICAL JOURNAL
2015年
4期
364-366,367
,共4页
产妇%子痫前期%脂联素%前列腺素E2%孕酮%皮质醇%载脂蛋白
產婦%子癇前期%脂聯素%前列腺素E2%孕酮%皮質醇%載脂蛋白
산부%자간전기%지련소%전렬선소E2%잉동%피질순%재지단백
Puerpera%Preeclampsia%Adiponectin%PGE2%Progesterone%Cortisol%Apolipoprotein
目的：探讨正常妊娠和子痫前期产妇脂联素、前列腺素 E2（PGE2）、孕酮、皮质醇和载脂蛋白水平改变情况，为明确子痫前期病因和临床早期诊断治疗提供依据。方法分别采用放射免疫法、酶联免疫吸附实验、免疫透射比浊法和化学发光等方法对60例子痫前期产妇和60例正常孕妇不同孕周的脂联素、PGE2、孕酮、皮质醇和载脂蛋白水平进行检测。结果随着孕周的增加，正常组产妇脂联素并无明显改变（ P＞0.05），而PGE2水平、载脂蛋白各项指标、孕酮和皮质醇水平则均逐渐增加，差异均具有统计学意义（ P＜0.05）。与正常组比较，子痫前期组的Apo－A1、Apo－B100、Apo－CIII水平未见明显差异（ P＞0.05），而子痫前期组的PGE2水平在分娩和妊娠28周时均明显低于正常组，脂联素则仅在分娩时显著低于正常组（ P＞0.05）；Apo－CII测量值在妊娠早、中、晚期均明显高于正常组（P＜0.05），而子痫前期组的孕酮和皮质醇水平仅在分娩时明显改变（P＜0.05），而其余时间点组间比较无显著差异（ P＞0.05）。结论脂联素、PGE2、孕酮、皮质醇和Apo－CII水平异常是导致子痫前期的重要因素，可作为诊断和治疗子痫前期的潜在生物标志。
目的：探討正常妊娠和子癇前期產婦脂聯素、前列腺素 E2（PGE2）、孕酮、皮質醇和載脂蛋白水平改變情況，為明確子癇前期病因和臨床早期診斷治療提供依據。方法分彆採用放射免疫法、酶聯免疫吸附實驗、免疫透射比濁法和化學髮光等方法對60例子癇前期產婦和60例正常孕婦不同孕週的脂聯素、PGE2、孕酮、皮質醇和載脂蛋白水平進行檢測。結果隨著孕週的增加，正常組產婦脂聯素併無明顯改變（ P＞0.05），而PGE2水平、載脂蛋白各項指標、孕酮和皮質醇水平則均逐漸增加，差異均具有統計學意義（ P＜0.05）。與正常組比較，子癇前期組的Apo－A1、Apo－B100、Apo－CIII水平未見明顯差異（ P＞0.05），而子癇前期組的PGE2水平在分娩和妊娠28週時均明顯低于正常組，脂聯素則僅在分娩時顯著低于正常組（ P＞0.05）；Apo－CII測量值在妊娠早、中、晚期均明顯高于正常組（P＜0.05），而子癇前期組的孕酮和皮質醇水平僅在分娩時明顯改變（P＜0.05），而其餘時間點組間比較無顯著差異（ P＞0.05）。結論脂聯素、PGE2、孕酮、皮質醇和Apo－CII水平異常是導緻子癇前期的重要因素，可作為診斷和治療子癇前期的潛在生物標誌。
목적：탐토정상임신화자간전기산부지련소、전렬선소 E2（PGE2）、잉동、피질순화재지단백수평개변정황，위명학자간전기병인화림상조기진단치료제공의거。방법분별채용방사면역법、매련면역흡부실험、면역투사비탁법화화학발광등방법대60례자간전기산부화60례정상잉부불동잉주적지련소、PGE2、잉동、피질순화재지단백수평진행검측。결과수착잉주적증가，정상조산부지련소병무명현개변（ P＞0.05），이PGE2수평、재지단백각항지표、잉동화피질순수평칙균축점증가，차이균구유통계학의의（ P＜0.05）。여정상조비교，자간전기조적Apo－A1、Apo－B100、Apo－CIII수평미견명현차이（ P＞0.05），이자간전기조적PGE2수평재분면화임신28주시균명현저우정상조，지련소칙부재분면시현저저우정상조（ P＞0.05）；Apo－CII측량치재임신조、중、만기균명현고우정상조（P＜0.05），이자간전기조적잉동화피질순수평부재분면시명현개변（P＜0.05），이기여시간점조간비교무현저차이（ P＞0.05）。결론지련소、PGE2、잉동、피질순화Apo－CII수평이상시도치자간전기적중요인소，가작위진단화치료자간전기적잠재생물표지。
Ob jective To investigate the changes of adiponectin , PGE2, progesterone, cortisol and apolipoprotein in both normal preg-nancy and preeclampsia pregnant , and reveal the cause of disease and provide the basis for early clinical diagnosis and treatment .Methods The levels of adiponectin, PGE2, progesterone, cortisol and apolipoprotein were detected by using radioimmunoassay , enzyme-linked immunosorbent assay , immune turbidimetric method and chemiluminescence etc respectively in the 60 normal pregnant and 60 preeclampsia cases.Results Adiponectin did not change significantly in both groups with increasing gestational age (P>0.05), whereas the PGE2 levels, apolipoprotein progesterone and cortisol were significantly enhanced (P<0.05).Compared with normal group, there was no significant change in Apo-A1, Apo-B100 and Apo-CIII, but in the preeclampsia cases, PGE2 was significantly lower than the normal group at both 28 weeks of pregnancy and the delivery time , while adiponectin was significantly decreased at 28 weeks of pregnancy (P>0.05).No-tably, in the preeclampsia at each tested time, the levels of Apo-CII were significantly higher than the normal group (P<0.05), while the progesterone and cortisol levels were significantly changed in the normal group at delivery time (P<0.05).But there wasn′t significant change at other time points among groups (P>0.05).Conclusion Adiponectin, PGE2, progesterone, cortisol and Apo-CII are the im-portant factors for preeclampsia , and also, these indicators can be used as the potential diagnostic and therapeutic biomarkers .
