CAJ | 학술논문

目的：通过对血铅水平异常者的病例对照研究，探讨血铅水平对铅作业工人血压及心电图的影响。方法选取某钢铁厂确诊为职业性慢性血铅水平异常者45人（慢性血铅中毒20人，慢性血铅升高25人）为病例组，同时选取该厂不接触铅的工人30人为对照组，监测血压、心电图等检查结果进行对比分析。结果收缩压水平从高到低依次为慢性血铅中毒组[（126．0±11．4）mmHg]、慢性血铅升高组[（120．6±8．99）mmHg]和对照组[（112．5±5．2）mmHg]，组间两两比较差异均具有统计学意义（P＜0．05）；舒张压水平从高到低依次为慢性血铅中毒组[（76．3±9．0）mmHg]、慢性血铅升高组[（72．4 ± 6．8）mmHg]和对照组[（68．7±4．7）mmHg]，组间两两比较差异均具有统计学意义（P＜0．05）；各类心电图异常总体检出率从高到低依次为慢性血铅中毒组（65．0％）、慢性血铅升高组（40．0％）和对照组（16．7％），差异具有统计学意义（趋势χ2值＝11．930，P＝0．001）。结论铅可导致收缩压与舒张压升高，以及心电图的异常率上升，且血铅水平越高上述问题越严重。
목적：통과대혈연수평이상자적병례대조연구，탐토혈연수평대연작업공인혈압급심전도적영향。방법선취모강철엄학진위직업성만성혈연수평이상자45인（만성혈연중독20인，만성혈연승고25인）위병례조，동시선취해엄불접촉연적공인30인위대조조，감측혈압、심전도등검사결과진행대비분석。결과수축압수평종고도저의차위만성혈연중독조[（126．0±11．4）mmHg]、만성혈연승고조[（120．6±8．99）mmHg]화대조조[（112．5±5．2）mmHg]，조간량량비교차이균구유통계학의의（P＜0．05）；서장압수평종고도저의차위만성혈연중독조[（76．3±9．0）mmHg]、만성혈연승고조[（72．4 ± 6．8）mmHg]화대조조[（68．7±4．7）mmHg]，조간량량비교차이균구유통계학의의（P＜0．05）；각류심전도이상총체검출솔종고도저의차위만성혈연중독조（65．0％）、만성혈연승고조（40．0％）화대조조（16．7％），차이구유통계학의의（추세χ2치＝11．930，P＝0．001）。결론연가도치수축압여서장압승고，이급심전도적이상솔상승，차혈연수평월고상술문제월엄중。
Objective Through the case-control study of the workers with abnormal blood lead level,to explore the effects of blood lead level on the blood pressure and electrocardiogram of the workers. Methods Forty-five workers from a certain steel works who were diag-nosed as having chronic abnormal blood lead level were selected (20 workers were diagnosed as chronic blood lead poisoning,25 workers were diagnosed as having chronic elevated blood lead)as the case group;meanwhile 30 workers from the same steel woks who had physical examination and out of touch with lead were selected as control group,then their blood pressure was monitored and electrocardiogram exami-nation results were analyzed. Results The systolic blood pressure levels of the workers from high to low in turn were chronic blood lead poi-soning group [(126. 0 ± 11. 4)mmHg],chronic elevated blood lead group [(120. 6 ± 8. 99)mmHg]and the control group [(112. 5 ± 5. 2)mmHg],and the comparative differences between any two groups were all statistically significant;the diastolic blood pressure levels of the workers from high to low in turn were chronic blood lead poisoning group [(76. 3 ± 9. 0 )mmHg ],chronic elevated blood lead group [(72. 4 ± 6. 8)mmHg]and the control group [(68. 7 ± 4. 7)mmHg],and the comparative differences between any two groups were all sta-tistically significant;the overall detection rate of all kinds of abnormal electrocardiogram (ECG)from high to low of the workers in turn was chronic blood lead poisoning group (65. 0%),chronic elevated blood lead group (40. 0%)and the control group(16. 7%)(χ2 =11. 930, P=0. 001). Conclusion Lead can result in higher systolic blood pressure and diastolic blood pressure,and a rising rate of abnormal ECG;moreover,the higher blood lead levels is,the more obvious of the above problems.