CAJ | 학술논문

结肠癌是临床上常见的恶性肿瘤，当前的化学药物治疗仍具有严重的毒、副作用，开发毒性低、副作用小的抗结肠癌药物的任务十分迫切。中草药的有效活性成分是筛选抗癌药物的重要来源，从天然植物中提取的多酚类、苷类、有机硫化物及异戊二烯类等物质可通过直接杀伤肿瘤细胞、阻滞细胞周期、影响基因表达、作用于凋亡信号传导途径和诱导细胞分化等机制在体外表现出显著的抑制人结肠癌 SW480细胞生长的活性。本文综述了近年来发现的具有体外抗 SW480细胞活性的天然植物单体。
결장암시림상상상견적악성종류，당전적화학약물치료잉구유엄중적독、부작용，개발독성저、부작용소적항결장암약물적임무십분박절。중초약적유효활성성분시사선항암약물적중요래원，종천연식물중제취적다분류、감류、유궤류화물급이무이희류등물질가통과직접살상종류세포、조체세포주기、영향기인표체、작용우조망신호전도도경화유도세포분화등궤제재체외표현출현저적억제인결장암 SW480세포생장적활성。본문종술료근년래발현적구유체외항 SW480세포활성적천연식물단체。
Human colon cancer is one of the most common malignant tumors. The current treatment of chemical drugs still has serious side effects and toxicity, therefore, it is very urgent to develop drugs with low side effects and toxicity for colon cancer patients. Enriched with active ingredients, Chinese herbal medicine becomes an important resource to screen anti-cancer drugs. Compounds of polyphenols, glycoside, organic sulfide and isoprenoids from natural plants are mark-edly characterized by their antitumor activities in vitro for human SW480 colon cancer cells, by killing tumor cells directly, blocking the cell cycle, affecting the gene expression and apoptosis signal pathways and induction of cell differentiation. This article makes a brief summary of monomers in anti-activity of SW480 cells from natural plant.