CAJ | 학술논문

目的：了解局部使用淫羊藿苷对正畸致炎性牙根吸收的影响。方法建立大鼠正畸牙移动模型，分别注射200 mg/kg 的淫羊藿苷(淫羊藿苷组)或生理盐水(阳性对照组)，左侧上颌为阴性对照组。通过 SEM、HE 及 TRAP 染色，观察牙根表面的吸收陷窝，并计算吸收陷窝率和 TRAP 阳性细胞数。结果淫羊藿苷组 SEM 吸收陷窝率和 TRAP阳性细胞数明显少于阳性对照组(P <0.05)；阴性对照组和阳性对照组测量值均有统计学差异(P <0.05)；淫羊藿苷组和阴性对照组 TRAP 阳性细胞数有统计学差异(P <0.05)，但 SEM 吸收陷窝率无统计学差异(P >0.05)。结论局部注射淫羊藿苷可降低正畸致炎性牙根吸收发生的程度。
목적：료해국부사용음양곽감대정기치염성아근흡수적영향。방법건립대서정기아이동모형，분별주사200 mg/kg 적음양곽감(음양곽감조)혹생리염수(양성대조조)，좌측상합위음성대조조。통과 SEM、HE 급 TRAP 염색，관찰아근표면적흡수함와，병계산흡수함와솔화 TRAP 양성세포수。결과음양곽감조 SEM 흡수함와솔화 TRAP양성세포수명현소우양성대조조(P <0.05)；음성대조조화양성대조조측량치균유통계학차이(P <0.05)；음양곽감조화음성대조조 TRAP 양성세포수유통계학차이(P <0.05)，단 SEM 흡수함와솔무통계학차이(P >0.05)。결론국부주사음양곽감가강저정기치염성아근흡수발생적정도。
Objective To study the influence of local administration of Icariin on orthodontically induced inflammatory root resorption (OIIRR ).Methods After rat models of orthodontic root movement were successfully established,rats were injected with 200 mg/kg Icariin (Icariin group)or saline (positive control group), respectively.Left maxillary served as the negative control group.The resorption pit of root surface was measured using scanning electron microscopy (SEM), HE staining, and tartrate resistant acid phosphatase (TRAP ). Results The level of TRAP positive cells and root resorption score in Icariin group were significantly lower than those in the positive control group (P < 0.05 ).Each measured value differed significantly between thenegative control group and the positive control group (P <0.05).The level of TRAP positive cells was significantly different (P <0.05),while root resorption scores did not differ between Icariin group and the negative control group (P >0.05).Conclusion Local administration of Icariin may reduce the degree of orthodontically induced resorption.