CAJ | 학술논문

目的：观察妇炎舒胶囊对苯酚胶浆剂致子宫内膜炎大鼠模型的影响，探讨其抗炎作用机制。方法雌性 SD 大鼠60只随机分为6组：假手术组(蒸馏水10 mL/kg)、模型组、金鸡胶囊组(0.65 g/kg)、妇炎舒胶囊大剂量组(1.8 g/kg)、妇炎舒胶囊中剂量组(0.9 g/kg)、妇炎舒胶囊小剂量组(0.45 g/kg)。采用子宫内注射苯酚胶浆剂致子宫内膜炎大鼠模型，连续给药28 d 后，检测大鼠子宫内膜的组织病理学改变，以及血清肿瘤坏死因子(TNF-α)及白细胞介素-2(IL-2)的变化。结果妇炎舒胶囊可降低大鼠子宫卵巢脏体比值，抑制病变子宫肿胀，改善子宫内膜上皮细胞增生、变性、坏死及炎细胞浸润等病理改变；大剂量妇炎舒胶囊还可降低大鼠血清 IL-2水平。结论妇炎舒胶囊对大鼠子宫内膜炎有治疗作用，其抗炎作用机制可能与降低 IL-2水平有关。
목적：관찰부염서효낭대분분효장제치자궁내막염대서모형적영향，탐토기항염작용궤제。방법자성 SD 대서60지수궤분위6조：가수술조(증류수10 mL/kg)、모형조、금계효낭조(0.65 g/kg)、부염서효낭대제량조(1.8 g/kg)、부염서효낭중제량조(0.9 g/kg)、부염서효낭소제량조(0.45 g/kg)。채용자궁내주사분분효장제치자궁내막염대서모형，련속급약28 d 후，검측대서자궁내막적조직병이학개변，이급혈청종류배사인자(TNF-α)급백세포개소-2(IL-2)적변화。결과부염서효낭가강저대서자궁란소장체비치，억제병변자궁종창，개선자궁내막상피세포증생、변성、배사급염세포침윤등병리개변；대제량부염서효낭환가강저대서혈청 IL-2수평。결론부염서효낭대대서자궁내막염유치료작용，기항염작용궤제가능여강저 IL-2수평유관。
Objective To observe the effects of Fuyanshu Capsule on phenol mucilage-induced endometritis rats and the possible anti-inflammation mechanism of the therapeutic effects.Methods Chronic endometritis in rats was induced by injection of phenol mucilage suspension into the uterus.Sixty female SD rats were randomly divided into 6 groups,namely,sham-operation group (distilled water,10mL/kg),model group,Jinji capsule group (0.65 g/kg),and Fuyanshu Capsule groups (1.8 g/kg,0.9 g/kg and 0.45 g/kg).After the rats were treated 28 days with corresponding medicine by intragastric administration,the pathology of the endometrium and changes of tumor necrosis factor α(TNF-α)and interleukin-2 (IL-2)levels were detected to evaluate the effects of Fuyanshu Capsule. Results Fuyanshu Capsule (1.8 g/kg and 0.9 g/kg)ameliorated the body weight reduction caused by endometritis in rats.Fuyanshu Capsule (1.8 g/kg,0.9 g/kg and 0.45 g/kg)reduced the ratio of the swelling uterus and ovaries to body weight of the rats.It ameliorated obviously the hyperplasia,necrosis and degeneration of endometrial epithelia and infiltration of inflammatory cells.The capsule (1.8 g/kg)decreased the serum IL-2 level in the rats with phenol mucilage-induced endometritis. Conclusion The anti-inflammatory effect of Fuyanshu Capsule on chronic endometritis induced by phenol mucilage in rats may be related to the decrease of IL-2 level.