CAJ | 학술논문

目的：探讨TP方案节拍化疗对局部晚期宫颈癌患者的临床疗效。方法选择78例宫颈鳞癌患者，Ⅰb期41例，Ⅱa期37例，将所有患者随机分为对照组及观察组，各39例。对照组患者采用常规TP方案进行化疗，观察组采用节拍化疗方案进行治疗，对化疗疗效、化疗毒副作用等进行分析。结果对照组治疗后总有效率为87．18％，观察组总有效率为84．62％，两组差异无统计学意义（P＞0．05）。观察组不良反应发生率低于对照组（P＜0．05）。两组治疗后CA125、CEA、SCCA较治疗前均显著下降（P＜0．05），但治疗后两组之间CA125、CEA、SCCA水平差异无统计学意义（P＞0．05）。结论 TP方案节拍化疗是治疗局部晚期宫颈癌的有效方案，较常规化疗方案可降低化疗毒副作用。
목적：탐토TP방안절박화료대국부만기궁경암환자적림상료효。방법선택78례궁경린암환자，Ⅰb기41례，Ⅱa기37례，장소유환자수궤분위대조조급관찰조，각39례。대조조환자채용상규TP방안진행화료，관찰조채용절박화료방안진행치료，대화료료효、화료독부작용등진행분석。결과대조조치료후총유효솔위87．18％，관찰조총유효솔위84．62％，량조차이무통계학의의（P＞0．05）。관찰조불량반응발생솔저우대조조（P＜0．05）。량조치료후CA125、CEA、SCCA교치료전균현저하강（P＜0．05），단치료후량조지간CA125、CEA、SCCA수평차이무통계학의의（P＞0．05）。결론 TP방안절박화료시치료국부만기궁경암적유효방안，교상규화료방안가강저화료독부작용。
Objective To study the clinical efficacy analysis of metronomic chemotherapy for locally advanced cervical cancer. Methods Seventy-eight cases of cervical squamous cell carcinoma patients in our hospital,includingⅠb of 41 cases,Ⅱa of 37 cases, were randomly divided into control group and observation group,with 39 cases in each group. The control group were treated with convention-al chemotherapy TP scheme,while the observation group accepted metronomic chemotherapy treatment for chemotherapy,then the side effects ,CA125,CEA,SCCA were analyzed. Results The total effective rate of the control group was 87. 18% and that in the observation group was 84. 62%,which showed no significant difference (P>0. 05). The incidence of adverse reactions in the observed group was significantly lower than that of the control group (P<0. 05). After treatment CA125,CEA,SCCA significantly decreased compared with before treatment (P<0. 05),but CA125,CEA,SCCA levels after treatment showed no significant difference (P>0. 05). Conclusion metronomic TP pro-gram is an effective chemotherapy for locally advanced cervical cancer,which can reduce the incidence of side effects of chemotherapy com-pared with conventional chemotherapy .