国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2015年
1期
33-36
,共4页
周春艳%王存德%李雪芹%董蕙
週春豔%王存德%李雪芹%董蕙
주춘염%왕존덕%리설근%동혜
感染%降钙素原%白细胞计数%恶性肿瘤
感染%降鈣素原%白細胞計數%噁性腫瘤
감염%강개소원%백세포계수%악성종류
Infections%Procalcitonin%White blood cell count%Malignant tumor
目的 探讨降钙素原(PCT)在恶性肿瘤合并细菌性感染诊断中的应用价值.方法 选取在云南省肿瘤医院就诊的60例经病原学确诊的恶性肿瘤伴细菌感染患者,35例排除感染的恶性肿瘤患者作为对照.采集患者静脉血检测血清PCT、WBC及中性粒细胞百分比(N％)水平,并对结果进行比对.结果 恶性肿瘤合并细菌感染的患者PCT、WBC及N％水平分别为1.23 (0.17～2.61) ng/mL、9.98 (7.65～13.29) ×109/L和(81.36±10.72)％,均高于对照组,且差异有统计学意义(Z=-7.359、-6.689,t=-9.550,P均＜0.01).60例患者中,PCT阳性率达100.00％,明显高于WBC的43.33％(26例)及N％的53.33％(32例),且差异有统计学意义(Fisher's确切概率法,P＜0.05).WBC及N％水平随着PCT水平升高也同时升高,但未见PCT水平与WBC或N％存在相关性(P均＞0.05).革兰阴性菌感染者的PCT水平为0.57(0.30～8.29) ng/mL,高于革兰阳性菌感染者(Z=-3.562,P＜0.01);全身感染者PCT、WBC及N％分别为8.73(8.29～12.75) ng/mL、12.59(8.11～12.82)×109/L和(85.41±8.54)％,均高于局部感染者,差异均有统计学意义(Z=-4.436,P＜0.01;Z=-2.182,P＜0.05; t=3.048,P＜0.01).结论 PCT比WBC及N％更能反映恶性肿瘤患者的感染状态,且可不受免疫抑制治疗的影响,同时也能在一定程度上反映感染菌株的类型及感染程度.
目的 探討降鈣素原(PCT)在噁性腫瘤閤併細菌性感染診斷中的應用價值.方法 選取在雲南省腫瘤醫院就診的60例經病原學確診的噁性腫瘤伴細菌感染患者,35例排除感染的噁性腫瘤患者作為對照.採集患者靜脈血檢測血清PCT、WBC及中性粒細胞百分比(N％)水平,併對結果進行比對.結果 噁性腫瘤閤併細菌感染的患者PCT、WBC及N％水平分彆為1.23 (0.17～2.61) ng/mL、9.98 (7.65～13.29) ×109/L和(81.36±10.72)％,均高于對照組,且差異有統計學意義(Z=-7.359、-6.689,t=-9.550,P均＜0.01).60例患者中,PCT暘性率達100.00％,明顯高于WBC的43.33％(26例)及N％的53.33％(32例),且差異有統計學意義(Fisher's確切概率法,P＜0.05).WBC及N％水平隨著PCT水平升高也同時升高,但未見PCT水平與WBC或N％存在相關性(P均＞0.05).革蘭陰性菌感染者的PCT水平為0.57(0.30～8.29) ng/mL,高于革蘭暘性菌感染者(Z=-3.562,P＜0.01);全身感染者PCT、WBC及N％分彆為8.73(8.29～12.75) ng/mL、12.59(8.11～12.82)×109/L和(85.41±8.54)％,均高于跼部感染者,差異均有統計學意義(Z=-4.436,P＜0.01;Z=-2.182,P＜0.05; t=3.048,P＜0.01).結論 PCT比WBC及N％更能反映噁性腫瘤患者的感染狀態,且可不受免疫抑製治療的影響,同時也能在一定程度上反映感染菌株的類型及感染程度.
목적 탐토강개소원(PCT)재악성종류합병세균성감염진단중적응용개치.방법 선취재운남성종류의원취진적60례경병원학학진적악성종류반세균감염환자,35례배제감염적악성종류환자작위대조.채집환자정맥혈검측혈청PCT、WBC급중성립세포백분비(N％)수평,병대결과진행비대.결과 악성종류합병세균감염적환자PCT、WBC급N％수평분별위1.23 (0.17～2.61) ng/mL、9.98 (7.65～13.29) ×109/L화(81.36±10.72)％,균고우대조조,차차이유통계학의의(Z=-7.359、-6.689,t=-9.550,P균＜0.01).60례환자중,PCT양성솔체100.00％,명현고우WBC적43.33％(26례)급N％적53.33％(32례),차차이유통계학의의(Fisher's학절개솔법,P＜0.05).WBC급N％수평수착PCT수평승고야동시승고,단미견PCT수평여WBC혹N％존재상관성(P균＞0.05).혁란음성균감염자적PCT수평위0.57(0.30～8.29) ng/mL,고우혁란양성균감염자(Z=-3.562,P＜0.01);전신감염자PCT、WBC급N％분별위8.73(8.29～12.75) ng/mL、12.59(8.11～12.82)×109/L화(85.41±8.54)％,균고우국부감염자,차이균유통계학의의(Z=-4.436,P＜0.01;Z=-2.182,P＜0.05; t=3.048,P＜0.01).결론 PCT비WBC급N％경능반영악성종류환자적감염상태,차가불수면역억제치료적영향,동시야능재일정정도상반영감염균주적류형급감염정도.
Objective To investigate the application value of procalcitonin(PCT) in diagnosis of malignant tumor complicated with bacterial infection.Methods Sixty cases of malignant tumors who were etiological diagnosed with bacterial infection were selected in Yunnan Tumor Hospital,and 35 cases of malignant tumor without infection were selected as control group.The venous blood samples were collected to detect serum PCT,WBC and the percentage of neutrophils (N％) level,and the results were compared.Result The level of PCT,WBC and N％ in patients with malignant tumors complicated with bacterial infection were 1.23(0.17-2.61) ng/mL,9.98 (7.65-13.29)×109/L and (81.36±10.72)％,which were all higher than the control group with significant differences (Z=-7.359,-6.689,t=-9.550,P all ＜0.01).The positive rate of PCT in 60 cases was 100.00％,which was significantly higher than that of WBC (43.33％,26 cases) and N％ (53.33％,32 cases),and the difference was statistically significant (Fisher's exact test,P＜0.05).The levels of WBC and N％ were elevated with the PCT level increasing,but no correlation was found between PCT level and WBC or N％ (P both ＞0.05).The PCT level in gram negative bacteria infections were 0.57 (0.30-8.29) ng/mL,and were higher than that of gram positive ones (Z=-3.562,P＜0.05).The level of PCT,WBC and N％ in general infections were 8.73 (8.29-12.75) ng/mL,12.59 (8.11-12.82) 109/L and (85.41±8.54)％,and were higher than local infections with significant differences (Z=-4.436,P＜0.01; Z=-2.182,P＜0.05; t=3.048,P＜0.01).Conclusions PCT can reflect the infection status of patients with malignant tumor more than WBC and N％.It is not affected by the impact of immunosuppressive treatment,while the PCT level may reflect the types of bacteria and infection status in a certain extent.
