中医学报
中醫學報
중의학보
China Journal of Chinese Medicine
2015年
5期
731-733
,共3页
中药保留灌肠%溃疡性结肠炎%肿瘤坏死因子-α%白介素-6
中藥保留灌腸%潰瘍性結腸炎%腫瘤壞死因子-α%白介素-6
중약보류관장%궤양성결장염%종류배사인자-α%백개소-6
retention enema of traditional Chinese medicine%ulcerative colitis%tumor necrosis factor-α%interleukin-6
目的：观察中药保留灌肠治疗溃疡性结肠炎的疗效以及对血清炎症因子水平的影响。方法：102例溃疡性结肠炎患者随机分为对照组和观察组，每组各51例。对照组给予口服柳氮磺吡啶治疗，每次1．5～2．0 g，每日3次；观察组给予中药保留灌肠治疗，15 d为1个疗程。治疗4个疗程后采用ELISA法检测血清肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）和白介素-6（interleukin-6，IL-6）的浓度，同时观察两组患者腹痛、腹泻、黏液脓血便、里急后重等症状体征改善情况并结合肠镜检查比较两组患者临床疗效。结果：两组患者治疗后血清TNF-α和IL-6水平较治疗前相比均明显下降（P＜0．05），但观察组患者下降程度甚于对照组（P＜0．05）。观察组患者各种症状改善率明显优于对照组（P＜0．05）。对照组有效率为84．31％，观察组有效率为96．08％，两组比较，差异有统计学意义（P＜0．05）。结论：中药保留灌肠治疗溃疡性结肠炎能够显著抑制患者体内炎症因子水平，临床疗效显著。
目的：觀察中藥保留灌腸治療潰瘍性結腸炎的療效以及對血清炎癥因子水平的影響。方法：102例潰瘍性結腸炎患者隨機分為對照組和觀察組，每組各51例。對照組給予口服柳氮磺吡啶治療，每次1．5～2．0 g，每日3次；觀察組給予中藥保留灌腸治療，15 d為1箇療程。治療4箇療程後採用ELISA法檢測血清腫瘤壞死因子-α（tumor necrosis factor-α，TNF-α）和白介素-6（interleukin-6，IL-6）的濃度，同時觀察兩組患者腹痛、腹瀉、黏液膿血便、裏急後重等癥狀體徵改善情況併結閤腸鏡檢查比較兩組患者臨床療效。結果：兩組患者治療後血清TNF-α和IL-6水平較治療前相比均明顯下降（P＜0．05），但觀察組患者下降程度甚于對照組（P＜0．05）。觀察組患者各種癥狀改善率明顯優于對照組（P＜0．05）。對照組有效率為84．31％，觀察組有效率為96．08％，兩組比較，差異有統計學意義（P＜0．05）。結論：中藥保留灌腸治療潰瘍性結腸炎能夠顯著抑製患者體內炎癥因子水平，臨床療效顯著。
목적：관찰중약보류관장치료궤양성결장염적료효이급대혈청염증인자수평적영향。방법：102례궤양성결장염환자수궤분위대조조화관찰조，매조각51례。대조조급여구복류담광필정치료，매차1．5～2．0 g，매일3차；관찰조급여중약보류관장치료，15 d위1개료정。치료4개료정후채용ELISA법검측혈청종류배사인자-α（tumor necrosis factor-α，TNF-α）화백개소-6（interleukin-6，IL-6）적농도，동시관찰량조환자복통、복사、점액농혈편、리급후중등증상체정개선정황병결합장경검사비교량조환자림상료효。결과：량조환자치료후혈청TNF-α화IL-6수평교치료전상비균명현하강（P＜0．05），단관찰조환자하강정도심우대조조（P＜0．05）。관찰조환자각충증상개선솔명현우우대조조（P＜0．05）。대조조유효솔위84．31％，관찰조유효솔위96．08％，량조비교，차이유통계학의의（P＜0．05）。결론：중약보류관장치료궤양성결장염능구현저억제환자체내염증인자수평，림상료효현저。
Objective:To investigate Influence of retention enema of traditional Chinese medicine on serum levels of inflammatory factors of ulcerative colitis patients.Methods:102 cases of ulcerative colitis patients were randomly divided into control group(n=51)and ob-servation group (n=51).The control group was treated with Sulfasalazine,1.5 -2.0 g each time and 3 times a day.The observation group received retention enema of traditional Chinese medicine for 4 courses and 15 days as a course.Serum TNF-αand IL-6 levels were detected using double antibody sandwich enzyme linked immunosorbent assay (ELISA).Clinical symptoms such as abdominal pain,diarrhea,mucous stool with pus and blood,tenesmus signs of two groups were analyzed.Clinical curative effects of two groups were analyzed by colonoscopy.Results:Before treatment,there was no difference of serum TNF- alpha and IL-6 levels in two groups (P>0. 05).After treatment,serum TNF-and IL-6 levels of two groups decreased significantly compared with before treatment(P<0.05). Serum TNF-αand IL-6 levels in the observation group decreased more significantly than that of the control group(P<0.05 ).After treatment,Clinical symptoms in the two groups improved significantly(P<0.05).And the observation group improved more significant-ly than the control group(P<0.05).The total effective rate of the two groups was 84.31%and 96.08%.The total effective rate of ob-servation group was higher than that of control group(P<0.05).Conclusion:Retention enema of traditional Chinese medicine can sig-nificantly inhibit the levels of inflammatory factors in patients with ulcerative colitis and has significant clinical efficacy.
