中医学报
中醫學報
중의학보
China Journal of Chinese Medicine
2015年
5期
728-730
,共3页
慢性肝炎肝纤维化%鳖甲丹红化纤方%血清标志物%肝功能
慢性肝炎肝纖維化%鱉甲丹紅化纖方%血清標誌物%肝功能
만성간염간섬유화%별갑단홍화섬방%혈청표지물%간공능
liver fibrosis%since the proposed red turtle JiaDan chemical fiber party%liver fibrosis serological markers%liver function
目的：观察自拟鳖甲丹红化纤方治疗慢性肝炎肝纤维化的临床疗效及对肝纤维化血清标志物的影响。方法：90例慢性肝炎肝纤维化患者随机分为治疗组和对照组各45例，两组均给予护肝降酶等常规治疗，治疗组在常规治疗上加自拟鳖甲丹红化纤方。对照组在基础常规治疗上加重组干扰素α-2α50×106 U，肌肉注射，每两日1次。8周为1个疗程，6个疗程后观察疗效。结果：治疗后两组丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血清胆红素较治疗前明显降低（P＜0．05），且治疗组低于对照组（P＜0．01），治疗后两组血清白蛋白、血清球蛋白变化不明显，差异无统计学意义（P＞0．05）；两组透明质酸、层黏连蛋白、Ⅲ型前胶原及IV型胶原均较治疗前降低，且治疗组下降幅度大于对照组，差异有统计学意义（P＜0．05）；两组肝脏回声、门静脉内径、脾静脉内径、脾脏厚度均有减轻，但治疗组较为明显，差异有统计学意义（P＜0．05）；治疗组有效率为91．11％，对照组为73．33％，差异有统计学意义（P＜0．01）。结论：自拟鳖甲丹红化纤方能抑制肝炎肝纤维化，改善肝功能，对肝炎肝纤维化有良好的临床疗效。
目的：觀察自擬鱉甲丹紅化纖方治療慢性肝炎肝纖維化的臨床療效及對肝纖維化血清標誌物的影響。方法：90例慢性肝炎肝纖維化患者隨機分為治療組和對照組各45例，兩組均給予護肝降酶等常規治療，治療組在常規治療上加自擬鱉甲丹紅化纖方。對照組在基礎常規治療上加重組榦擾素α-2α50×106 U，肌肉註射，每兩日1次。8週為1箇療程，6箇療程後觀察療效。結果：治療後兩組丙氨痠氨基轉移酶、天鼕氨痠氨基轉移酶、血清膽紅素較治療前明顯降低（P＜0．05），且治療組低于對照組（P＜0．01），治療後兩組血清白蛋白、血清毬蛋白變化不明顯，差異無統計學意義（P＞0．05）；兩組透明質痠、層黏連蛋白、Ⅲ型前膠原及IV型膠原均較治療前降低，且治療組下降幅度大于對照組，差異有統計學意義（P＜0．05）；兩組肝髒迴聲、門靜脈內徑、脾靜脈內徑、脾髒厚度均有減輕，但治療組較為明顯，差異有統計學意義（P＜0．05）；治療組有效率為91．11％，對照組為73．33％，差異有統計學意義（P＜0．01）。結論：自擬鱉甲丹紅化纖方能抑製肝炎肝纖維化，改善肝功能，對肝炎肝纖維化有良好的臨床療效。
목적：관찰자의별갑단홍화섬방치료만성간염간섬유화적림상료효급대간섬유화혈청표지물적영향。방법：90례만성간염간섬유화환자수궤분위치료조화대조조각45례，량조균급여호간강매등상규치료，치료조재상규치료상가자의별갑단홍화섬방。대조조재기출상규치료상가중조간우소α-2α50×106 U，기육주사，매량일1차。8주위1개료정，6개료정후관찰료효。결과：치료후량조병안산안기전이매、천동안산안기전이매、혈청담홍소교치료전명현강저（P＜0．05），차치료조저우대조조（P＜0．01），치료후량조혈청백단백、혈청구단백변화불명현，차이무통계학의의（P＞0．05）；량조투명질산、층점련단백、Ⅲ형전효원급IV형효원균교치료전강저，차치료조하강폭도대우대조조，차이유통계학의의（P＜0．05）；량조간장회성、문정맥내경、비정맥내경、비장후도균유감경，단치료조교위명현，차이유통계학의의（P＜0．05）；치료조유효솔위91．11％，대조조위73．33％，차이유통계학의의（P＜0．01）。결론：자의별갑단홍화섬방능억제간염간섬유화，개선간공능，대간염간섬유화유량호적림상료효。
Objective:To discuss the clinical curative effect of Biejia Danhong Huaxian Prescription treatment of hepatitis liver fiber and its influence on serum liver fibrosis markers.Methods:90 patients were randomly divided into treatment group and control group,each of 45 cases.Two groups both were given conventional treatment such as protecting liver and lowering enzyme,and the treatment group was given additionally self-made Biejia Danhong Huaxian Prescription.The control group on the basis of conventional treatment with recom-binant interferonα-2α5 million units,intramuscular,once every two days.After a course of 8 weeks,6 course of treatment.Results:Two groups after treatment of ALT,AST,TBiL,significantly lower than before treatment (P<0.05),and the treatment group was lower than the control group(P<0.01),the two groups after treatment does not change significantly propagated,GLB,there was no statistically sig-nificant difference (P>0.05);two groups of HA,LN,PC Ⅲ and IV-C was reduced and the and the treatment group decreased more than the control group,the difference was statistically significant (P<0.05);two groups of liver echo,portal vein diameter,inner diam-eter and thickness of the spleen and spleen vein with ease,but the treatment group is more obvious,the difference was statistically sig-nificant;The treatment group total effectiveness 91.11%,control group was 73.33%,the difference was statistically significant(P<0. 01);Conclusion:Self-made Biejia Danhong Huaxian Prescription can restrain hepatitis liver fibrosis,improve liver meritorious serv-ice,which has good clinical curative effect on hepatitis liver fibrosis.
