临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2015年
6期
1070-1072,1073
,共4页
李晓艳%申孟平%宫红梅%张冰%贾冬梅
李曉豔%申孟平%宮紅梅%張冰%賈鼕梅
리효염%신맹평%궁홍매%장빙%가동매
新生儿%持续肺动脉高压%危险因素%Logistic
新生兒%持續肺動脈高壓%危險因素%Logistic
신생인%지속폐동맥고압%위험인소%Logistic
newborn%persistent pulmonary hypertension%risk factors%Logistic
目的：探讨新生儿持续肺动脉高压的高危因素及早期预测方法。方法按照病例对照研究设计,对50例新生儿持续肺动脉高压病例和同期无PPHN的相对健康儿50例对照组进行相关因素的回顾性调查,采用Logistic回归方法进行单因素和多因素分析,在此基础上建立新生儿持续肺动脉高压发病的预测模型,并对模型进行初步评价。结果感染性肺炎( OR=43．665)、新生儿窒息( OR=33．682)、先天性心脏病(OR=30．548)、性别(OR=18．337)、宫内窘迫(OR=17．727)、混合性酸中毒(OR=7．975)、出生体重(OR=1．002)为新生儿持续肺动脉高压发病的主要危险因素。预测回归模型P=1/1+Exp∑(-13．511+2．909X1+3．777X2+3．517X3+2．875X4+3．419X5+2．076X6)的适配度的Chi-square检验结果为86．807,提示P<0．01,模型有显著性意义。结论新生儿持续肺动脉高压是多因素综合的结果,对高危患儿应尽早采取措施,减少患病率及死亡率。
目的：探討新生兒持續肺動脈高壓的高危因素及早期預測方法。方法按照病例對照研究設計,對50例新生兒持續肺動脈高壓病例和同期無PPHN的相對健康兒50例對照組進行相關因素的迴顧性調查,採用Logistic迴歸方法進行單因素和多因素分析,在此基礎上建立新生兒持續肺動脈高壓髮病的預測模型,併對模型進行初步評價。結果感染性肺炎( OR=43．665)、新生兒窒息( OR=33．682)、先天性心髒病(OR=30．548)、性彆(OR=18．337)、宮內窘迫(OR=17．727)、混閤性痠中毒(OR=7．975)、齣生體重(OR=1．002)為新生兒持續肺動脈高壓髮病的主要危險因素。預測迴歸模型P=1/1+Exp∑(-13．511+2．909X1+3．777X2+3．517X3+2．875X4+3．419X5+2．076X6)的適配度的Chi-square檢驗結果為86．807,提示P<0．01,模型有顯著性意義。結論新生兒持續肺動脈高壓是多因素綜閤的結果,對高危患兒應儘早採取措施,減少患病率及死亡率。
목적：탐토신생인지속폐동맥고압적고위인소급조기예측방법。방법안조병례대조연구설계,대50례신생인지속폐동맥고압병례화동기무PPHN적상대건강인50례대조조진행상관인소적회고성조사,채용Logistic회귀방법진행단인소화다인소분석,재차기출상건립신생인지속폐동맥고압발병적예측모형,병대모형진행초보평개。결과감염성폐염( OR=43．665)、신생인질식( OR=33．682)、선천성심장병(OR=30．548)、성별(OR=18．337)、궁내군박(OR=17．727)、혼합성산중독(OR=7．975)、출생체중(OR=1．002)위신생인지속폐동맥고압발병적주요위험인소。예측회귀모형P=1/1+Exp∑(-13．511+2．909X1+3．777X2+3．517X3+2．875X4+3．419X5+2．076X6)적괄배도적Chi-square검험결과위86．807,제시P<0．01,모형유현저성의의。결론신생인지속폐동맥고압시다인소종합적결과,대고위환인응진조채취조시,감소환병솔급사망솔。
Objective To explore the risk factors and prediction for newborns with persistent pulmonary hy-pertension ( NPPH) . Methods An case-control study was conducted in 50 newborns of persistent pulmonary hyper-tension. All factors were used as independent variables for multivariate analysis of Logistic regression, and a predic-tive model of Logistic regression for the genesis of PPHN was established, and the model was evaluated preliminarily. Results The main risk factors included infectious pneumonia (OR=43. 665), neonatal asphyxia (OR=33. 682), congenital heart disease (OR=30. 548), gender (OR=18. 337), intrauterine distress (OR=17. 727), mixed aci-dosis ( OR=7. 975 ) and birth weight ( OR =1. 002 ) . Goodness of fit for predictive model of Logistic regression checked by Chi-square was 86. 807. It indicated model check{P=1/1+Exp∑( -13. 511+2. 909X1 +3. 777X2 +3. 517X3 +2. 875X4 +3. 419X5 +2. 076X6)} was statistically significant (P<0. 01). Conclusion Persistent pul-monary hypertension of the newborn is the result of multiple factors, and they should be taken measures to reduce morbidity and mortality as soon as possible.
