CAJ | 학술논문

目的：探讨侧脑室置管外引流持续脑室灌注给药加腰大池引流治疗颅内感染临床效果。方法选取2012－01～2013－10间我院神经外科收治手术后发生颅内感染60例患者，随机分为观察组和对照组，对照组采用反复多次腰穿鞘内注射给药治疗颅内感染，观察组采用侧脑室置管外引流持续脑室灌注给药加腰大池引流治疗颅内感染，比较两组治疗效果、后遗症发生情况及生活质量等。结果两组患者治疗后均无死亡，观察组治疗总有效率为93.33％，明显高于对照组70.00％的总有效率，两组比较差异有统计学意义（ P＜0.05）；观察组后遗症发生率为6.67％，明显低于对照组33.33％的发生率，两组比较差异有统计学意义（P＜0.05）；观察组生活质量各项评分均高于对照组，两组间各值比较差异有统计学意义（P＜0.05）。结论侧脑室置管外引流持续脑室灌注给药加腰大池引流治疗颅内感染可提高治疗效果，降低后遗症发生率，改善患者生活质量，具有显著的临床治疗效果，值得临床推广应用。
목적：탐토측뇌실치관외인류지속뇌실관주급약가요대지인류치료로내감염림상효과。방법선취2012－01～2013－10간아원신경외과수치수술후발생로내감염60례환자，수궤분위관찰조화대조조，대조조채용반복다차요천초내주사급약치료로내감염，관찰조채용측뇌실치관외인류지속뇌실관주급약가요대지인류치료로내감염，비교량조치료효과、후유증발생정황급생활질량등。결과량조환자치료후균무사망，관찰조치료총유효솔위93.33％，명현고우대조조70.00％적총유효솔，량조비교차이유통계학의의（ P＜0.05）；관찰조후유증발생솔위6.67％，명현저우대조조33.33％적발생솔，량조비교차이유통계학의의（P＜0.05）；관찰조생활질량각항평분균고우대조조，량조간각치비교차이유통계학의의（P＜0.05）。결론측뇌실치관외인류지속뇌실관주급약가요대지인류치료로내감염가제고치료효과，강저후유증발생솔，개선환자생활질량，구유현저적림상치료효과，치득림상추엄응용。
Objective To investigate the lateral ventricle drainage ventricle infusion continued lumbar cerebrospinal fluid drainage clinical effect of treatment of intracranial infection .Methods 60 patients with intracranial infection admitted to the Department of Neurosurgery were randomly divided into observation group and control group from January , 2012 to October , 2013 .The control group used repeated lum-bar intrathecal administration in the treatment of intracranial infection , and the observation group used lateral ventricular drainage of ventri-cle infusion administration continued lumbar cerebrospinal fluid drainage in the treatment of intracranial infection .Sequelae and the inci-dence of quality of life of treatment effects were compared between the two groups .Results There was no death in the two groups after treat-ment.Total effective rate of observation group was 93.33%, which was significantly higher than the efficiency of 70.00% in the control group.The difference of the two groups was statistically significant (P<0.05).In the observation group, the sequelae rate was 6.67%, which was lower than that of the control group 33.33%.There was statistical significance of the two groups ( P<0.05); Quality of life scores of observation group was higher than that of control group , and the values between the two groups were statistically significant ( P<0.05 ).Conclusion Lateral ventricle drainage ventricle infusion continued lumbar cerebrospinal fluid drainage in the treatment of intracranial infection can improve the therapeutic effect , reduce the incidence of sequelae , and improve the life quality of patients , with sig-nificant clinical therapeutic effect .So it is worthy of popularization in clinical application .