医学分子生物学杂志
醫學分子生物學雜誌
의학분자생물학잡지
FOREIGN MEDICAL SCIENCES
2015年
2期
111-115
,共5页
轴突%线粒体%细胞骨架%钙离子%miro
軸突%線粒體%細胞骨架%鈣離子%miro
축돌%선립체%세포골가%개리자%miro
axon%mitochondria%cytoskeleton%calcium
线粒体是重要的细胞器，其在细胞内的分布与细胞生长及活动密切相关。线粒体的锚定机制不仅是分子生物学中非常基础的问题，也与多种神经疾病密切相关，对其进行探讨是一件非常有意义的事情。文章将分别从线粒体内外两个角度，围绕钙离子对马达蛋白及其调节器的调节，对线粒体在微管和微丝的锚定机制进行探讨。相信随着线粒体锚定机制的进一步阐明，多种神经疾病的防治将得到进一步的发展。
線粒體是重要的細胞器，其在細胞內的分佈與細胞生長及活動密切相關。線粒體的錨定機製不僅是分子生物學中非常基礎的問題，也與多種神經疾病密切相關，對其進行探討是一件非常有意義的事情。文章將分彆從線粒體內外兩箇角度，圍繞鈣離子對馬達蛋白及其調節器的調節，對線粒體在微管和微絲的錨定機製進行探討。相信隨著線粒體錨定機製的進一步闡明，多種神經疾病的防治將得到進一步的髮展。
선립체시중요적세포기，기재세포내적분포여세포생장급활동밀절상관。선립체적묘정궤제불부시분자생물학중비상기출적문제，야여다충신경질병밀절상관，대기진행탐토시일건비상유의의적사정。문장장분별종선립체내외량개각도，위요개리자대마체단백급기조절기적조절，대선립체재미관화미사적묘정궤제진행탐토。상신수착선립체묘정궤제적진일보천명，다충신경질병적방치장득도진일보적발전。
Mitochondria are important organelles, and their distribution in cells is closely relat-ed to cell growth and activities. It is meaningful to examine the anchoring mechanism of mitochondri-a, as it is not only fundamental for molecular biology, but also closely related to a variety of neuro-logical diseases. The present study focuses on the regulation of motor proteins and their regulators by calcium, and discusses about the anchoring mechanism of inner and outer mitochondria on microtu-bule and actin filament. With the anchoring mechanism of mitochondria being elucidated, numerous neurological diseases will be prevented and cured.
