CAJ | 학술논문

乙肝病毒或丙肝病毒(hepatitis B virus or hepatitis C virus, HBV/ HCV)感染是肝脏慢性疾病最常见原因。 Kupffer 细胞(KC)定植于肝血窦中,是机体数量最多的内脏巨噬细胞,在 HBV/ HCV 病毒感染后肝脏慢性炎症疾病发展中扮演了极为重要的角色。 KC 通过各种信号通路影响细胞因子的分泌及细胞间作用,调节着机体的炎性反应和免疫活动。它的激活决定着炎症和抗炎的平衡,维持机体的内环境的稳态。研究 KC 对了解肝脏 HBV/ HCV 感染的致病机制及治疗有重要意义。
을간병독혹병간병독(hepatitis B virus or hepatitis C virus, HBV/ HCV)감염시간장만성질병최상견원인。 Kupffer 세포(KC)정식우간혈두중,시궤체수량최다적내장거서세포,재 HBV/ HCV 병독감염후간장만성염증질병발전중분연료겁위중요적각색。 KC 통과각충신호통로영향세포인자적분비급세포간작용,조절착궤체적염성반응화면역활동。타적격활결정착염증화항염적평형,유지궤체적내배경적은태。연구 KC 대료해간장 HBV/ HCV 감염적치병궤제급치료유중요의의。
Hepatitis B or C virus (HBV/ HCV) infections are the most common cause of chron-ic liver disease. Kupffer cells (KCs), located in the hepatic sinusoid, are the visceral macrophages of greatest number, and they play an extremely important role in the development of liver chronic inflammation after HBV/ HCV infection. KCs affect the secretion of cytokines and interaction between cells through a variety of signaling pathways, and regulate the inflammatory response and immune activity. The activation of KC is the key to the balance of inflammation and anti-inflammation, and it maintains the stability of the internal environment. Studies on KC are of great importance for the un-derstanding of the pathogenic mechanisms and treatment of HBV/ HCV infections.