CAJ | 학술논문

目的：分析克拉霉素对儿童咳嗽变异性哮喘气道炎症的影响以及疗效，探讨其临床适用性。方法选取从2011年5月至2013年9月于我院接受治疗的92例咳嗽变异性哮喘患儿作为研究资料，按照随机数表法将患者随机分为治疗组和对照组两组，对照组采用基础治疗方案进行治疗，治疗组在对照组的基础上采用克拉霉素进行治疗。观察并记录两组患儿治疗前后肺功能和ACT评分，治疗后两组患儿诱导痰中各种白细胞数量、炎性细胞因子水平以及临床疗效，并进行比较。结果两组患者治疗后肺部功能以及ACT评分明显高于治疗前，治疗组患儿肺部功能以及ACT评分明显优于对照组，差异有统计学意义( P<0．05)；治疗后，治疗组患儿诱导痰中各种白细胞数量明显低于对照组，而炎性细胞因子水平中IL-2高于对照组， TNF-α、IL-6低于对照组，差异均具有统计学意义( P<0．05)；治疗组患儿总有效率为84．8%，而对照组为65．2%，两组对比，差异具有统计学意义(P<0．05)。结论克拉霉素对儿童咳嗽变异性哮喘疗效显著，可以减少气道炎症，改善肺功能，适合临床长期推广应用。
목적：분석극랍매소대인동해수변이성효천기도염증적영향이급료효，탐토기림상괄용성。방법선취종2011년5월지2013년9월우아원접수치료적92례해수변이성효천환인작위연구자료，안조수궤수표법장환자수궤분위치료조화대조조량조，대조조채용기출치료방안진행치료，치료조재대조조적기출상채용극랍매소진행치료。관찰병기록량조환인치료전후폐공능화ACT평분，치료후량조환인유도담중각충백세포수량、염성세포인자수평이급림상료효，병진행비교。결과량조환자치료후폐부공능이급ACT평분명현고우치료전，치료조환인폐부공능이급ACT평분명현우우대조조，차이유통계학의의( P<0．05)；치료후，치료조환인유도담중각충백세포수량명현저우대조조，이염성세포인자수평중IL-2고우대조조， TNF-α、IL-6저우대조조，차이균구유통계학의의( P<0．05)；치료조환인총유효솔위84．8%，이대조조위65．2%，량조대비，차이구유통계학의의(P<0．05)。결론극랍매소대인동해수변이성효천료효현저，가이감소기도염증，개선폐공능，괄합림상장기추엄응용。
Objective To analyze the influence and efficacy of clarithromycin on children with cough variant asthma airway in-flammation. Methods 92 children with cough and asthma from May 2011 to September 2013 were were randomly divided into the treatment group and the control group. The control group was given basic regimen, and the treatment group was additionally treated with clarithromycin on the basis of the control group. Their lung function, ACT scores, white blood cell count in induced sputum, inflamma-tory cytokine levels and clinical efficacy of the two groups were compared after the treatment. Results After the treatment, their lung function and ACT score of the two groups was significantly higher than before, and the improvement was more pronounced in the treat-ment group than in the control group (P<0. 05). After the treatment, the count of white blood cell in induced sputum and the levels of TNF-α and IL-6 was significantly lower in the treatment group than in the control group, while the level of IL-2 was significantly higher in the treatment group than in the control group ( P<0. 05 ) . The total effective rate of the treatment group was 84. 8%, and 65. 2% of the control group (P<0. 05). Conclusion Clarithromycin has good curative effect in the treatment of children with cough variant asthma, which can reduce airway inflammation and improve lung function.