CAJ | 학술논문

骆驼蓬中的多种成分都可以抑制瘤株生长，在消化道肿瘤中表现尤为突出。目前研究结果显示，骆驼蓬是通过诱导肿瘤细胞凋亡、抑制增殖以起到抗肿瘤作用，但仅有少数研究涉及信号通路等。今后的研究可以从以下几个方面进行：①骆驼蓬中总生物碱具有较强的杀菌作用，其杀菌作用和抗肿瘤作用之间是否存在关联，可以作为机制研究的突破口之一；②以往的研究多集中在骆驼蓬碱、去氢骆驼蓬碱等总体成分上，用质谱法分离出高纯度咔啉类生物碱，相当于中医的“小复方”，以此为基础开展细胞、动物研究，可能成为新的研究思路；③骆驼蓬全草具有毒性，应注意研究其安全用量，避免过量中毒情况发生。
락타봉중적다충성분도가이억제류주생장，재소화도종류중표현우위돌출。목전연구결과현시，락타봉시통과유도종류세포조망、억제증식이기도항종류작용，단부유소수연구섭급신호통로등。금후적연구가이종이하궤개방면진행：①락타봉중총생물감구유교강적살균작용，기살균작용화항종류작용지간시부존재관련，가이작위궤제연구적돌파구지일；②이왕적연구다집중재락타봉감、거경락타봉감등총체성분상，용질보법분리출고순도잡람류생물감，상당우중의적“소복방”，이차위기출개전세포、동물연구，가능성위신적연구사로；③락타봉전초구유독성，응주의연구기안전용량，피면과량중독정황발생。
Many ingredients in harmel can inhibit tumor growth,especially in digestive tract.At present,the results shows that harmel can resist tumor by induce tumor cell apoptosis,But only a handful of research involved in signaling pathways,etc.Next,we can research in following aspects:①the total alkaloids in the harmel has strong sterilization effect,whether has a connection between bactericidal ac-tion and antitumor effect,can be used as one of the breakthrough of mechanism research.more than previous studies focused on the o-verall composition,such as harmine,harmine hydrochloride,using mass spectrometry to isolate high purity carbolines alkaloid,equal to Chinese herbal compound prescription,on this basis,we can carry out the studies of cells and animals,be likely to a new research idea.③The whole herb of harmel is toxic,we should study the safety dosage,avoid excessive poisoning cases.