CAJ | 학술논문

目的：分析慢性阻塞性肺疾病急性加重期（AECOPD）患者临床特点及相关危险因素，以提高临床治疗水平。方法：收集2012－2014年我院呼吸内科50例 AECOPD 患者的临床资料，另外选取50例 COPD 稳定期患者为对照组，分析两组患者临床特征及危险因素，并比较 AECOPD 患者治疗前、后血气分析、降钙素原（PCT ）变化情况。结果：（1）分析示吸烟史、营养不良、住院次数、合并症、反复应用抗菌药物等为 COPD 患者急性加重的危险因素（P＜0．05）。（2）AECOPD 患者治疗前、后动脉氧分压、二氧化碳分压及降钙素原明显改善（P ＜0．05）。结论：AECOPD 临床特征明显，血气分析可作为 AECOPD 患者病情控制的判断指标，而 PCT 可作为 AECOPD 患者细菌感染的标志物，可指导临床抗菌药物的选择。
목적：분석만성조새성폐질병급성가중기（AECOPD）환자림상특점급상관위험인소，이제고림상치료수평。방법：수집2012－2014년아원호흡내과50례 AECOPD 환자적림상자료，령외선취50례 COPD 은정기환자위대조조，분석량조환자림상특정급위험인소，병비교 AECOPD 환자치료전、후혈기분석、강개소원（PCT ）변화정황。결과：（1）분석시흡연사、영양불량、주원차수、합병증、반복응용항균약물등위 COPD 환자급성가중적위험인소（P＜0．05）。（2）AECOPD 환자치료전、후동맥양분압、이양화탄분압급강개소원명현개선（P ＜0．05）。 결론：AECOPD 림상특정명현，혈기분석가작위 AECOPD 환자병정공제적판단지표，이 PCT 가작위 AECOPD 환자세균감염적표지물，가지도림상항균약물적선택。
Objective :Analysis of patients with chronic obstructive pulmonary disease (AECOPD) of exacerbations clinical characteristics and related risk factors ,in order to improve the level of clinical treatment .Methods :Collect our hospital in 2012 to 2014 respiratory medicine clinical data of 50 patients with AECOPD ,while selecting 50 patients with COPD stabilization for the control group ,analyzed two groups of patients with clinical characteristics and risk factors , and compare the AECOPD patients’blood gas analysis before and after the treatment ,Procalcitonin (PCT ) .Results :(1)Analysis of smoking history ,malnutrition ,hospitalization time ,complications ,such as repeated application of anti‐microbial agents for the risk factors of acute exacerbation of COPD patients (P< 0 .05) .(2)AECOPD patients before and after treatment of arterial oxygen partial pressure ,CO2 partial pressure and Procalcitonin improved significantly (P< 0 .05) .Conclusion :AECOPD clinical features ,blood gas analysis can be used as AECOPD patients control the judg‐ment of the indicators ,and PCT can be used as AECOPD patients with bacterial infection markers ,can guide clinical selection of antimicrobial drugs .