白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2015年
3期
173-177
,共5页
苏红%徐梦微%李建国%王晋芬
囌紅%徐夢微%李建國%王晉芬
소홍%서몽미%리건국%왕진분
淋巴瘤%EB病毒%EB病毒编码的RNA%EBV潜伏膜蛋白
淋巴瘤%EB病毒%EB病毒編碼的RNA%EBV潛伏膜蛋白
림파류%EB병독%EB병독편마적RNA%EBV잠복막단백
Lymphoma%Epstein-Barr virus%Epstein-Barr virus encoded RNAs%Latent membrane protein 1
目的 探讨不同类型淋巴瘤中EB病毒(EBV)的分布特点.方法 选用免疫组织化学EnVision法标记ALK1、CD3、CD5、CD7、CD10、CD15、CD20、CD23、CD30、CD38、CD43、CD56、CD68、CD79、CD99、CyclinD1、EMA、TdT与EBV潜伏膜蛋白(LMP-1),原位杂交技术标记EBV编码的RNA(EBER).按照2008年WHO淋巴造血系统肿瘤分类标准对存档的438例淋巴瘤组织标本重新分类.结果 在B细胞非霍奇金淋巴瘤(B-NHL)、NK/T细胞淋巴瘤和霍奇金淋巴瘤(HL)中EBER阳性率分别是5.4%(14/261)、16.5%(19/115)和59.7%(37/62),LMP-1阳性率分别为5.4%(14/261)、5.2%(6/115)和59.7%(37/62).弥漫大B细胞淋巴瘤(DLBCL)患者中,EBER在60岁以上组中的阳性率(13.2%,7/53)明显高于60岁及以下组(1.2%,1/81)(P<0.05);在NK/T细胞淋巴瘤中LMP-1蛋白表达与EBER表达具有不一致性,EBER阳性率明显高于LMP-1(P<0.05);5例鼻型NK/T细胞淋巴瘤中全部表达EBER;在HL淋巴瘤中LMP-1蛋白表达与EBER表达具有一致性.结论 EBV感染与淋巴瘤类型相关,EBV在鼻型NK/T细胞淋巴瘤中表达率高,HL次之.鉴于EBER与LMP-1在HL中的一致性表达,出于经济学考虑,LMP-1可代替EBER用作EBV的检测.EBV可能在鼻型NK/T细胞淋巴瘤、HL等的发生、发展中有重要作用.
目的 探討不同類型淋巴瘤中EB病毒(EBV)的分佈特點.方法 選用免疫組織化學EnVision法標記ALK1、CD3、CD5、CD7、CD10、CD15、CD20、CD23、CD30、CD38、CD43、CD56、CD68、CD79、CD99、CyclinD1、EMA、TdT與EBV潛伏膜蛋白(LMP-1),原位雜交技術標記EBV編碼的RNA(EBER).按照2008年WHO淋巴造血繫統腫瘤分類標準對存檔的438例淋巴瘤組織標本重新分類.結果 在B細胞非霍奇金淋巴瘤(B-NHL)、NK/T細胞淋巴瘤和霍奇金淋巴瘤(HL)中EBER暘性率分彆是5.4%(14/261)、16.5%(19/115)和59.7%(37/62),LMP-1暘性率分彆為5.4%(14/261)、5.2%(6/115)和59.7%(37/62).瀰漫大B細胞淋巴瘤(DLBCL)患者中,EBER在60歲以上組中的暘性率(13.2%,7/53)明顯高于60歲及以下組(1.2%,1/81)(P<0.05);在NK/T細胞淋巴瘤中LMP-1蛋白錶達與EBER錶達具有不一緻性,EBER暘性率明顯高于LMP-1(P<0.05);5例鼻型NK/T細胞淋巴瘤中全部錶達EBER;在HL淋巴瘤中LMP-1蛋白錶達與EBER錶達具有一緻性.結論 EBV感染與淋巴瘤類型相關,EBV在鼻型NK/T細胞淋巴瘤中錶達率高,HL次之.鑒于EBER與LMP-1在HL中的一緻性錶達,齣于經濟學攷慮,LMP-1可代替EBER用作EBV的檢測.EBV可能在鼻型NK/T細胞淋巴瘤、HL等的髮生、髮展中有重要作用.
목적 탐토불동류형림파류중EB병독(EBV)적분포특점.방법 선용면역조직화학EnVision법표기ALK1、CD3、CD5、CD7、CD10、CD15、CD20、CD23、CD30、CD38、CD43、CD56、CD68、CD79、CD99、CyclinD1、EMA、TdT여EBV잠복막단백(LMP-1),원위잡교기술표기EBV편마적RNA(EBER).안조2008년WHO림파조혈계통종류분류표준대존당적438례림파류조직표본중신분류.결과 재B세포비곽기금림파류(B-NHL)、NK/T세포림파류화곽기금림파류(HL)중EBER양성솔분별시5.4%(14/261)、16.5%(19/115)화59.7%(37/62),LMP-1양성솔분별위5.4%(14/261)、5.2%(6/115)화59.7%(37/62).미만대B세포림파류(DLBCL)환자중,EBER재60세이상조중적양성솔(13.2%,7/53)명현고우60세급이하조(1.2%,1/81)(P<0.05);재NK/T세포림파류중LMP-1단백표체여EBER표체구유불일치성,EBER양성솔명현고우LMP-1(P<0.05);5례비형NK/T세포림파류중전부표체EBER;재HL림파류중LMP-1단백표체여EBER표체구유일치성.결론 EBV감염여림파류류형상관,EBV재비형NK/T세포림파류중표체솔고,HL차지.감우EBER여LMP-1재HL중적일치성표체,출우경제학고필,LMP-1가대체EBER용작EBV적검측.EBV가능재비형NK/T세포림파류、HL등적발생、발전중유중요작용.
Objective To investigate the distribution characteristics of the Epstein-Barr virus (EBV)in lymphomas.Methods 438 cases of lymphomas were reclassified according to the WHO classification of lymphoma (2008).ALK1,CD3,CD5,CD7,CD10,CD15,CD20,CD23,CD30,CD43,CD56,CD68,CD79,CD99,CyclinD1,EMA,IgD,TdT,Vs38C and LMP-1 were detected by in situ hybridization of EBER and immunohistochemistry.Results In B cell lymphoma,T and NK cell lymphoma and Hodgkin' s lymphoma (HL),the positive rates of EBER were 5.4 % (14/261),16.5 % (19/115) and 59.7 % (37/62),respectively,and the positive rates of LMP-1 were 5.4 % (14/261),5.2 % (6/115) and 59.7 % (37/62).In DLBCL patients,EBER expression in the older group was significantly higher than that in the younger one [13.2 % (7/53) vs 1.2 % (1/81),P < 0.05].The expression of EBER and LMP-1 were inconsistent in T and NK cell lymphomas,and the positive rate of EBER was significantly higher than that of LMP-1 (P < 0.05).EBER was all positive in 5 cases of NK/T cell lymphoma-nasal type.The expression of EBER and LMP-1 were consistent in HL.Conclusion The EBV infection was associated with the classification of the lymphoma.The EBV infection was the highest in NK/T cell lymphoma-nasal type,and the next was in HL.Due to the consistency of EBER and LMP-1 expression in the HL,economically,LMP-1 may replace EBER as the indicator of EBV.EBV might play an important role in the occurrence and development of NK/T cell lymphoma-nasal type,HL and so on.