肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
3期
192-194
,共3页
胆囊肿瘤%纳米碳%淋巴结清扫%淋巴示踪剂
膽囊腫瘤%納米碳%淋巴結清掃%淋巴示蹤劑
담낭종류%납미탄%림파결청소%림파시종제
Gallbladder carcinoma%Carbon nanoparticles%Lymphadenectomy%Lymphatic tracer
目的 探讨新一代淋巴示踪剂纳米碳混悬液在胆囊癌淋巴结清扫中的应用价值.方法 选择2008年1月至2013年8月行胆囊癌根治术的患者21例,随机分入试验组(11例)及对照组(10例),试验组患者于入腹后在肿瘤边缘浆膜下注射纳米碳,对照组不用任何示踪剂,比较2组患者的淋巴结清扫结果.结果 试验组共清扫淋巴结138枚,平均每例清扫淋巴结(12.546±5.047)枚,对照组共清扫淋巴结87枚,平均每例(8.700±2.497)枚,两组差异有统计学意义(t=2.176,P=0.042).试验组患者淋巴结的黑染率为56.522％(78/138),黑染淋巴结79枚,转移46枚,阳性率58.228％;未黑染淋巴结59枚,转移23枚,阳性率38.983％,两者差异有统计学意义(P=0.039).未发现纳米碳导致患者局部及全身不良反应.结论 纳米碳混悬液有助于胆囊癌淋巴结清扫,可提高根治率,减少手术创伤,其使用是安全的.
目的 探討新一代淋巴示蹤劑納米碳混懸液在膽囊癌淋巴結清掃中的應用價值.方法 選擇2008年1月至2013年8月行膽囊癌根治術的患者21例,隨機分入試驗組(11例)及對照組(10例),試驗組患者于入腹後在腫瘤邊緣漿膜下註射納米碳,對照組不用任何示蹤劑,比較2組患者的淋巴結清掃結果.結果 試驗組共清掃淋巴結138枚,平均每例清掃淋巴結(12.546±5.047)枚,對照組共清掃淋巴結87枚,平均每例(8.700±2.497)枚,兩組差異有統計學意義(t=2.176,P=0.042).試驗組患者淋巴結的黑染率為56.522％(78/138),黑染淋巴結79枚,轉移46枚,暘性率58.228％;未黑染淋巴結59枚,轉移23枚,暘性率38.983％,兩者差異有統計學意義(P=0.039).未髮現納米碳導緻患者跼部及全身不良反應.結論 納米碳混懸液有助于膽囊癌淋巴結清掃,可提高根治率,減少手術創傷,其使用是安全的.
목적 탐토신일대림파시종제납미탄혼현액재담낭암림파결청소중적응용개치.방법 선택2008년1월지2013년8월행담낭암근치술적환자21례,수궤분입시험조(11례)급대조조(10례),시험조환자우입복후재종류변연장막하주사납미탄,대조조불용임하시종제,비교2조환자적림파결청소결과.결과 시험조공청소림파결138매,평균매례청소림파결(12.546±5.047)매,대조조공청소림파결87매,평균매례(8.700±2.497)매,량조차이유통계학의의(t=2.176,P=0.042).시험조환자림파결적흑염솔위56.522％(78/138),흑염림파결79매,전이46매,양성솔58.228％;미흑염림파결59매,전이23매,양성솔38.983％,량자차이유통계학의의(P=0.039).미발현납미탄도치환자국부급전신불량반응.결론 납미탄혼현액유조우담낭암림파결청소,가제고근치솔,감소수술창상,기사용시안전적.
Objective To evaluate the clinical value of carbon nanoparticles suspension in gallbladder carcinoma lymphadenectomy.Methods 21 cases of gallbladder carcinoma who received radical resection from January 2008 to August 2013 were randomly divided into experimental group (11 cases received carbon nanoparticles injection into the subserosa around the tumor before operation) and control group (10 cases did not receive any tracer).The number of dissected lymph nodes,black-stained lymph nodes and positive lymph nodes were analyzed.Results A total of 138 lymph nodes were resected in experiment group,average 12.546±5.047 lymph nodes per patient,which was significantly more than that in control group in which there were overall 87 lymph nodes,average 8.700±2.497 lymph nodes per patient (t =2.176,P =0.042).The blacken rate of lymph nodes in experimental group was 56.522 ％ (78/138).There were 46 metastasis lymph nodes out of 79 blacken lymph nodes,and the positive rate was significantly higher than that of non-blacken lymph nodes [58.228 ％ (46/79) vs 38.983 ％ (23/59),P=0.039].There was no local or systemic adverse reaction occurred in experimental group.Conclusions Carbon nanoparticles suspension maybe helpful for lymphadenectomy during radical gallbladder carcinoma dissection to reduce operating damage and be safe.
