肿瘤研究与临床
腫瘤研究與臨床
종류연구여림상
CANCER RESEARCH AND CLINIC
2015年
3期
187-189
,共3页
胸腺肿瘤%CD34%免疫组织化学
胸腺腫瘤%CD34%免疫組織化學
흉선종류%CD34%면역조직화학
Thymic tumor%CD34%Immunohistochemistry
目的 探讨CD34在胸腺肿瘤各亚型中的表达及其意义.方法 采用免疫组织化学SP法检测61例胸腺肿瘤组织石蜡切片中CD34的表达情况,计算微血管密度(MVD).根据2004 WHO胸腺肿瘤分型:A型7例,AB型9例,B1型16例,B2型10例,B3型10例,C型9例.结果 在A、AB、B1、B2、B3型及C型胸腺肿瘤中,MVD分别为3.78±2.12、5.72±2.79、7.51±3.34、10.89±5.10、12.31±4.08、16.51±6.24,表达水平呈逐渐增高趋势,差异有统计学意义(F=2.048,P=0.047);B2、B3、C型(中、高度危险组)与A、AB、B1型(无、低度危险组)之间差异有统计学意义(t=6.034,P＜0.05).结论 CD34的表达提示了MVD与胸腺肿瘤血管生成有关.CD34在胸腺肿瘤中的表达水平对胸腺肿瘤的良恶性程度判断可能具有重要的参考价值.
目的 探討CD34在胸腺腫瘤各亞型中的錶達及其意義.方法 採用免疫組織化學SP法檢測61例胸腺腫瘤組織石蠟切片中CD34的錶達情況,計算微血管密度(MVD).根據2004 WHO胸腺腫瘤分型:A型7例,AB型9例,B1型16例,B2型10例,B3型10例,C型9例.結果 在A、AB、B1、B2、B3型及C型胸腺腫瘤中,MVD分彆為3.78±2.12、5.72±2.79、7.51±3.34、10.89±5.10、12.31±4.08、16.51±6.24,錶達水平呈逐漸增高趨勢,差異有統計學意義(F=2.048,P=0.047);B2、B3、C型(中、高度危險組)與A、AB、B1型(無、低度危險組)之間差異有統計學意義(t=6.034,P＜0.05).結論 CD34的錶達提示瞭MVD與胸腺腫瘤血管生成有關.CD34在胸腺腫瘤中的錶達水平對胸腺腫瘤的良噁性程度判斷可能具有重要的參攷價值.
목적 탐토CD34재흉선종류각아형중적표체급기의의.방법 채용면역조직화학SP법검측61례흉선종류조직석사절편중CD34적표체정황,계산미혈관밀도(MVD).근거2004 WHO흉선종류분형:A형7례,AB형9례,B1형16례,B2형10례,B3형10례,C형9례.결과 재A、AB、B1、B2、B3형급C형흉선종류중,MVD분별위3.78±2.12、5.72±2.79、7.51±3.34、10.89±5.10、12.31±4.08、16.51±6.24,표체수평정축점증고추세,차이유통계학의의(F=2.048,P=0.047);B2、B3、C형(중、고도위험조)여A、AB、B1형(무、저도위험조)지간차이유통계학의의(t=6.034,P＜0.05).결론 CD34적표체제시료MVD여흉선종류혈관생성유관.CD34재흉선종류중적표체수평대흉선종류적량악성정도판단가능구유중요적삼고개치.
Objective To investigate the expression of CD34 and its clinical significances in different types of thymic tumor.Methods The expressions of CD34 in 61 thymic tumor tissues were detected by SP immunohistochemical method,then,the MVD was calculated.The patients included 7 cases of type A,9 cases of type AB,16 cases of type B1,10 cases of type B2,10 cases of type B3 and 9 cases of type C according to 2004 WHO Classification of thymic tumor.Results CD34 expression level was significantly increased from type A to type C.The MVDs were 3.78±2.12,5.72±2.79,7.51±3.34,10.89±5.10,12.31±4.08 and 16.51±6.24 in A,AB,B1,B2,B3 and C type of thymic tumor (F =2.048,P =0.047).The expression level in B2+B3+C type was significantly higher than A+AB+B1 type (t =6.034,P ＜ 0.05).Conclusions The expression of CD34 in different types of thymic tumor suggests that it may take some action in tumor-associated angiogenic function.Detection of CD34 may be useful to evaluate malignancy of thymic tumor.
