CAJ | 학술논문

目的：探讨CHOP方案对外周T细胞淋巴瘤（ PTCL）患者外周血中初始和记忆T细胞水平的变化及其临床意义。方法：采用流式细胞术检测20例PTCL患者CHOP方案化疗前后外周血中CD4＋CD45RA＋、CD4＋CD45RO＋、CD8＋CD45RA＋和CD8＋CD45 RO＋T 细胞的比例，分析疗效与 T 细胞亚群的关系。结果：PTCL 患者化疗前外周血中 CD4＋T 细胞、CD4＋CD45RO＋细胞的比例明显降低，CD4＋CD45RA＋、CD8＋、CD8＋CD45RO＋和CD8＋CD45RA＋T细胞的比例均明显升高（P＜0．05），而化疗后PTCL患者CD4＋、CD4＋CD45RO＋细胞的比例较治疗前升高， CD4＋CD45RA＋、CD8＋、CD8＋CD45RO＋和CD8＋CD45RA＋T细胞比例则较治疗前稍下降（P＜0．05）。治疗前后化疗有效组的CD4＋CD45RA＋均明显高于化疗无效组（P＜0．05）。结论：CHOP治疗对PTCL患者胸腺输出功能有一定的影响，伴有较高胸腺输出功能者对化疗效果更好。
목적：탐토CHOP방안대외주T세포림파류（ PTCL）환자외주혈중초시화기억T세포수평적변화급기림상의의。방법：채용류식세포술검측20례PTCL환자CHOP방안화료전후외주혈중CD4＋CD45RA＋、CD4＋CD45RO＋、CD8＋CD45RA＋화CD8＋CD45 RO＋T 세포적비례，분석료효여 T 세포아군적관계。결과：PTCL 환자화료전외주혈중 CD4＋T 세포、CD4＋CD45RO＋세포적비례명현강저，CD4＋CD45RA＋、CD8＋、CD8＋CD45RO＋화CD8＋CD45RA＋T세포적비례균명현승고（P＜0．05），이화료후PTCL환자CD4＋、CD4＋CD45RO＋세포적비례교치료전승고， CD4＋CD45RA＋、CD8＋、CD8＋CD45RO＋화CD8＋CD45RA＋T세포비례칙교치료전초하강（P＜0．05）。치료전후화료유효조적CD4＋CD45RA＋균명현고우화료무효조（P＜0．05）。결론：CHOP치료대PTCL환자흉선수출공능유일정적영향，반유교고흉선수출공능자대화료효과경호。
Objective:To explore the change of initial and memory T cells in peripheral blood and their clinical significance in peripheral T cell lymphoma patients( PTCL) before and after CHOP chemotherapy.Methods:The proportion of CD4+CD45RA+T cells and CD4+CD45RO+T cells,CD8+CD45RA+T cells and CD8+CD45RO+T cells in peripheral blood from 20 PTCL patients before and after chemotherapy was detected by flow cytometry, the relationship between curative effect and T cell subset was further analyzed.Results:Before treatment,the proportion of CD4+and CD4+CD45RO+T cells in PTCL patients was significantly lower than that from the control group,while the proportion of CD4+CD45RA+,CD8+,CD8+CD45RO+and CD8+CD45RA+T cells was significantly higher( P<0.05 );after treatment, proportion of CD4+, CD4+CD45RO+T was significantly increased, CD4+CD45RA+, CD8+, CD8+CD45RO+,CD8+CD45RA+T was slightly decreased( P<0.05).Before and after treatment,higher proportion of CD4+CD45RA+T cells was found in response group compared with no response group.Conclusion: CHOP chemotherapy might influence the thymic output function in PTCL patients,patients with higher thymic output function may have better response to chemotherapy.