CAJ | 학술논문

目的：观察多索茶碱静脉滴注联合布地奈德雾化吸入治疗对支气管哮喘急性发作患者的疗效。方法选取确诊支气管哮喘急性发作患者160例，以随机数字表法分为观察组与对照组，每组各80例。对照组给予以布地奈德雾化吸入为主的常规综合治疗措施，观察组在对照组的基础上给予多索茶碱静脉滴注，连续使用5～7 d。比较两组治疗前后的血沉（ ESR）、血清C-反应蛋白（ CRP）、痰液嗜酸性粒细胞（ Eos）百分比，肺功能指标，包括用力肺活量（ FVC）、第1 s用力呼气容积（ FEV1）、第1 s用力呼气量百分率（FEV1％）、峰值流速（PEF），比较治疗后临床疗效及过程中的不良反应情况。结果治疗前，两组患者血清ESR、CRP、痰Eos 以及FVC、FEV1、FEV1％、PEF 比较，差异均无统计学意义（ P ＞0.05）；治疗后，两组患者血清ESR、CRP以及痰Eos均有不同程度的降低（tESR ＝3.57，tCRP ＝3.72，tEos ＝6.25），FVC、FEV1、FEV1％、PEF不同程度的升高（tFVC ＝3.98，tFEV1＝3.42，tFEV1％＝6.30，tPEF ＝3.16），与治疗前比较，差异具有统计学意义（ P＜0.05），且观察组患者血清ESR、CRP以及痰Eos均低于对照组水平（tESR ＝4.86，tCRP ＝3.51，tEos ＝5.63），FVC、FEV1、FEV1％、PEF均高于对照组水平（tFVC ＝4.11，tFEV1＝3.60，tFEV1％＝5.82），差异具有统计学意义（P ＜0.05）。观察组与对照组总有效率分别为92.50％、83.75％（χ2＝3.59，P＜0.05），不良反应发生率均为3.75％（ P＞0.05）。结论多索茶碱静脉滴注联合布地奈德雾化吸入治疗支气管哮喘急性发作，能够快速抑制过度的炎症反应，迅速缓解临床症状，患者依从性好，值得临床治疗中推广应用。
목적：관찰다색다감정맥적주연합포지내덕무화흡입치료대지기관효천급성발작환자적료효。방법선취학진지기관효천급성발작환자160례，이수궤수자표법분위관찰조여대조조，매조각80례。대조조급여이포지내덕무화흡입위주적상규종합치료조시，관찰조재대조조적기출상급여다색다감정맥적주，련속사용5～7 d。비교량조치료전후적혈침（ ESR）、혈청C-반응단백（ CRP）、담액기산성립세포（ Eos）백분비，폐공능지표，포괄용력폐활량（ FVC）、제1 s용력호기용적（ FEV1）、제1 s용력호기량백분솔（FEV1％）、봉치류속（PEF），비교치료후림상료효급과정중적불량반응정황。결과치료전，량조환자혈청ESR、CRP、담Eos 이급FVC、FEV1、FEV1％、PEF 비교，차이균무통계학의의（ P ＞0.05）；치료후，량조환자혈청ESR、CRP이급담Eos균유불동정도적강저（tESR ＝3.57，tCRP ＝3.72，tEos ＝6.25），FVC、FEV1、FEV1％、PEF불동정도적승고（tFVC ＝3.98，tFEV1＝3.42，tFEV1％＝6.30，tPEF ＝3.16），여치료전비교，차이구유통계학의의（ P＜0.05），차관찰조환자혈청ESR、CRP이급담Eos균저우대조조수평（tESR ＝4.86，tCRP ＝3.51，tEos ＝5.63），FVC、FEV1、FEV1％、PEF균고우대조조수평（tFVC ＝4.11，tFEV1＝3.60，tFEV1％＝5.82），차이구유통계학의의（P ＜0.05）。관찰조여대조조총유효솔분별위92.50％、83.75％（χ2＝3.59，P＜0.05），불량반응발생솔균위3.75％（ P＞0.05）。결론다색다감정맥적주연합포지내덕무화흡입치료지기관효천급성발작，능구쾌속억제과도적염증반응，신속완해림상증상，환자의종성호，치득림상치료중추엄응용。
Objective To observe the curative effect of intervenous drop infusion of doxofylline combined with budesonide inhalation therapy for patients with acute exacerbation of bronchial asthma .Methods One hundred sixty patients with acute exacerbation of bronchial asthma were randomly divided into observation group and control group .Patients of control group were given conventional treatment measures of budesonide inhalation therapy , the observation group were given intervenous drop infusion of doxofylline combined with budesonide inhalation therapy continuously for 5 to 7days.The erythrocyte sedimentation rate (ESR), serum C-reactive pro-tein (CRP), sputum eosinophils (Eos) percentage, lung function parameter including forced vital capacity (FVC), forced expiratory volume in the first 1s (FEV1), percentage of first 1s forced expiratory volume ( FEV1%) and peak flow rate ( PEF) were compared before and after treatment.The curative effect of treatment and adverse reactions in the process were compared between two groups .Results The differences in serum ESR , CRP, sputum Eos, FVC, FEV, FEV1%and PEF of patients between two groups were not significant ( P>0.05 ) before treat-ment, while after treatment the serum ESR , CRP, sputum Eos of two group were significantly decreased (tESR =3.57, tCRP =3.72, tEos =6.25), and the FVC, FEV1, FEV1% and PEF were significantly increased (tFVC =3.98, tFEV1 =3.42, tFEV1% =6.30, tPEF =3.16) (P<0.05 or P<0.01 ) .The serum ESR , CRP and Eos sputum levels of observation group were signifi-cant lower than that of control group (tESR =4.86, tCRP =3.51, tEos =5.63), while the FVC, FEV1 , FEV1%, PEF levels of observation group were significant higher than that of the control group (tFVC =4.11, tFEV1 =3.60, tFEV1% =5.82).The total effective rate of observation group and control group were 92.50%and 83.75%respectively (χ2 =3.59 , P<0.05 ) , the adverse reaction rates of two groups were all 3.75% ( P>0.05 ) .Conclusion The intervenous drop infusion of doxofylline combined with budesonide inhalation therapy for acute exacerbation of bronchial asthma can suppress excessive inflammation and relieve symptoms quickly , and the compliance of patient was good , it is worthy of promotion and application in clinical treatment .