CAJ | 학술논문

目的：研究新生儿发生医院感染的细菌分布特点与耐药性，为临床治疗提供参考。方法回顾性分析2012－2014年150例新生儿发生医院感染的细菌培养及药敏试验结果，数据采用WHO‐NET5．4进行统计处理。结果共1238例新生儿送检标本中150例培养阳性，感染率12．1％；150例感染新生儿中有32例新生儿发生复合感染，复合感染率21．3％；共检出182株病原菌，以革兰阴性菌为主，共112株占61．5％；4种主要革兰阴性菌对亚胺培南、环丙沙星、阿米卡星较为敏感，铜绿假单胞菌对头孢类抗菌药物耐药率＞50．0％；耐甲氧西林金黄色葡萄球菌仅对万古霉素敏感，对其他各种抗菌药物的耐药性均高于甲氧西林敏感金黄色葡萄球菌。结论临床应根据药敏试验合理选择抗菌药物。
목적：연구신생인발생의원감염적세균분포특점여내약성，위림상치료제공삼고。방법회고성분석2012－2014년150례신생인발생의원감염적세균배양급약민시험결과，수거채용WHO‐NET5．4진행통계처리。결과공1238례신생인송검표본중150례배양양성，감염솔12．1％；150례감염신생인중유32례신생인발생복합감염，복합감염솔21．3％；공검출182주병원균，이혁란음성균위주，공112주점61．5％；4충주요혁란음성균대아알배남、배병사성、아미잡성교위민감，동록가단포균대두포류항균약물내약솔＞50．0％；내갑양서림금황색포도구균부대만고매소민감，대기타각충항균약물적내약성균고우갑양서림민감금황색포도구균。결론림상응근거약민시험합리선택항균약물。
OBJECTIVE To study neonatal bacteria distribution and drug resistance of nosocomial infections ,so as to provide the reference for the clinical treatment .METHODS The bacteria culture and drug sensitive test results of 150 cases of neonatal nosocomial infections were analyzed retrospectively from 2012 to 2014 .All data were sta‐tistically analyzed by WHO‐NET 5 .4 software .RESULTS A total of 150 cases were detected to be bacteria posi‐tive in the all 1238 neonatal cases and the infection rate was 12 .1% .Among the 150 cases ,32 cases proved to be combined infections with the rate of 21 .3% .Totally 182 strains of pathogens were detected .Gram‐negative bacte‐ria dominated the majority with 112 strains ,accounting for 61 .5% .The 4 main gram‐negative bacteria were sensi‐tive to imipenem ciprofloxacin and amikacin .More than 50% Pseudomonas aeruginosa were resistant to cephalo‐sporin .Methicillin‐resistant Staphylococcus epidermidis were only sensiti to vancomycin and had high drug resist‐ance rate than other antibiotics to methicillin‐resistant Staphylococcus epidermidis .CONCLUSION Antibiotics should be chosen reasonably according to the drug sensitive test in clinic .