CAJ | 학술논문

目的：评价中性粒细胞CD64指数在淋巴瘤患者化疗后合并细菌感染中检测及早期诊断的价值。方法选取106例淋巴瘤患者，根据临床症状、体征和微生物学检测结果分为细菌感染组（51例）和非细菌感染组（55例），健康对照组30例，应用流式细胞仪检测中性粒细胞表面CD64指数，同时检测血清C反应蛋白和白细胞数（ WBC）。结果化疗后合并细菌感染的淋巴瘤患者组CD64指数显著高于非感染组及健康对照组，差异均具有显著的统计学意义（ P＜0.01）。通过ROC曲线分析，CD64指数对化疗后合并细菌感染的诊断优于CRP和WBC计数。结论 CD64指数可作为淋巴瘤化疗后合并细菌感染的早期诊断、鉴别诊断的指标，指导抗菌药物应用。
목적：평개중성립세포CD64지수재림파류환자화료후합병세균감염중검측급조기진단적개치。방법선취106례림파류환자，근거림상증상、체정화미생물학검측결과분위세균감염조（51례）화비세균감염조（55례），건강대조조30례，응용류식세포의검측중성립세포표면CD64지수，동시검측혈청C반응단백화백세포수（ WBC）。결과화료후합병세균감염적림파류환자조CD64지수현저고우비감염조급건강대조조，차이균구유현저적통계학의의（ P＜0.01）。통과ROC곡선분석，CD64지수대화료후합병세균감염적진단우우CRP화WBC계수。결론 CD64지수가작위림파류화료후합병세균감염적조기진단、감별진단적지표，지도항균약물응용。
Objective To explore the early diagnosis value of neutrophil CD 64 index in lym-phoma patients with infection after chemotherapy .Methods One hundred and six patients with lymphoma were divided into infection group ( n=51 ) and un-infection group ( n=55 ) ac-cording to symptoms and microbiological test results , and 30 healthy person were as control . Levels of CD64, CRP and WBC were measured .Results Expressions of CD64 in infection group were higher than those in control group ( P<0.05 ) .ROC curve showed that CD 64 index was superior to CRP and WBC in diagnosis of infection of lymphoma patients after chemothera-py.Conclusion The CD64 index can be used as a marker of early diagnosis and differential diagnosis in lymphoma patients after chemotherapy complicated with infection , and guide the application of anti-bacterial drugs .