临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
8期
655-657,658
,共4页
急性冠脉综合征%五聚素3 预后
急性冠脈綜閤徵%五聚素3 預後
급성관맥종합정%오취소3 예후
Acute coronary syndrome%Pentraxin3%Prognosis
目的:探讨急性冠脉综合征(ACS)患者血清五聚素3(PTX3)的水平及对近期预后判断的意义。方法随机选取2013年12月至2014年8月心内科住院的冠心病患者156例,其中稳定性心绞痛( SA)患者38例,ACS患者118例,包括不稳定性心绞痛(UAP)患者64例,急性心肌梗死(AMI)患者54例;采用ELISA法检测各组入院时血清PTX3水平及ACS组患者正规治疗7天后血清PTX3水平。在出院6月后对患者进行随访,了解患者近期预后,对PTX3水平与预后做相关性分析。结果 ACS组患者PTX3水平显著高于SA组患者( SA组:874.56±128.25 pg/ml,UAP组:1354.74±254.94 pg/ml,AMI组:1474.27±278.18 pg/ml),( P ﹤0.05);ACS组7天后PTX3水平较入院时明显降低(UAP组入院时:1354.74±254.94 pg/ml,7天后:1035.37±249.13 pg/ml,AMI组入院时:1474.27±278.18 pg/ml,7天后:1067.35±264.58 pg/ml)( P ﹤0.05);血清PTX3、hs-CRP、LDL-C与ACS患者近期预后相关( P ﹤0.05)。结论 ACS患者血清PTX3表达升高,且提示近期预后不良。
目的:探討急性冠脈綜閤徵(ACS)患者血清五聚素3(PTX3)的水平及對近期預後判斷的意義。方法隨機選取2013年12月至2014年8月心內科住院的冠心病患者156例,其中穩定性心絞痛( SA)患者38例,ACS患者118例,包括不穩定性心絞痛(UAP)患者64例,急性心肌梗死(AMI)患者54例;採用ELISA法檢測各組入院時血清PTX3水平及ACS組患者正規治療7天後血清PTX3水平。在齣院6月後對患者進行隨訪,瞭解患者近期預後,對PTX3水平與預後做相關性分析。結果 ACS組患者PTX3水平顯著高于SA組患者( SA組:874.56±128.25 pg/ml,UAP組:1354.74±254.94 pg/ml,AMI組:1474.27±278.18 pg/ml),( P ﹤0.05);ACS組7天後PTX3水平較入院時明顯降低(UAP組入院時:1354.74±254.94 pg/ml,7天後:1035.37±249.13 pg/ml,AMI組入院時:1474.27±278.18 pg/ml,7天後:1067.35±264.58 pg/ml)( P ﹤0.05);血清PTX3、hs-CRP、LDL-C與ACS患者近期預後相關( P ﹤0.05)。結論 ACS患者血清PTX3錶達升高,且提示近期預後不良。
목적:탐토급성관맥종합정(ACS)환자혈청오취소3(PTX3)적수평급대근기예후판단적의의。방법수궤선취2013년12월지2014년8월심내과주원적관심병환자156례,기중은정성심교통( SA)환자38례,ACS환자118례,포괄불은정성심교통(UAP)환자64례,급성심기경사(AMI)환자54례;채용ELISA법검측각조입원시혈청PTX3수평급ACS조환자정규치료7천후혈청PTX3수평。재출원6월후대환자진행수방,료해환자근기예후,대PTX3수평여예후주상관성분석。결과 ACS조환자PTX3수평현저고우SA조환자( SA조:874.56±128.25 pg/ml,UAP조:1354.74±254.94 pg/ml,AMI조:1474.27±278.18 pg/ml),( P ﹤0.05);ACS조7천후PTX3수평교입원시명현강저(UAP조입원시:1354.74±254.94 pg/ml,7천후:1035.37±249.13 pg/ml,AMI조입원시:1474.27±278.18 pg/ml,7천후:1067.35±264.58 pg/ml)( P ﹤0.05);혈청PTX3、hs-CRP、LDL-C여ACS환자근기예후상관( P ﹤0.05)。결론 ACS환자혈청PTX3표체승고,차제시근기예후불량。
Objective To explore the relationship between serum level of Pentraxin 3 and short-term prognosis in patients with acute coro-nary syndrome( ACS). Methods A total of 156 patients with coronary artery disease including 38 patients with stable angina pectoris( SAP),64 patients with unstable angina pectoris(UAP)and 54 patients with acute myocardial infarction(AMI)were enrolled in this study. Serum level of PTX3 was detected by ELISA at admission and after treatment for one week in ACS group. The short-term prognosis of patients with ACS had been followed up by phone at 6 months later. Results The serum level of TPX3 in ACS group was significantly higher than that of SAP group( SAP group:874. 56 ± 128. 25 pg/ml),UAP group(1 354. 74 ± 254. 94 pg/ml),and AMI group(1 474. 27 ± 278. 18 pg/ml)( P ﹤0. 05). The serum level of TPX3 in ACS group was significantly decreased after 7 days than that at admission(UAP group at admission:1 354.74 ±254.94 pg/ml,7 days later:1 035. 37 ± 249. 13 pg/ml),and AMI group at admission:(1 474. 27 ± 278. 18 pg/ml,7 days later:1 067. 35 ± 264. 58 pg/ml)( P ﹤0. 05). The short-term prognosis of patients with ACS was closely correlated with serum levels of PTX3,hs-CRP and LDL-C( P ﹤0. 05). Conclusion Serum level of PTX3 is significantly elevated in patients with ACS,and the increased serum level of PTX3 indicates poor short-term prognosis in patients with ACS.