CAJ | 학술논문

目的：分析患者泌尿生殖道感染解脲脲支原体对抗菌药物的敏感性，为临床合理使用抗菌药物提供依据。方法回顾性分析2008年1月－2013年10月妇产科、泌尿外科门诊送检的解脲脲支原体培养阳性3280例患者的临床资料及药敏数据，采用WHONET进行统计分析。结果不同性别泌尿生殖道感染患者解脲脲支原体对米诺环素、多西环素均有很高的敏感性，敏感率＞90．0％；2008－2013年解脲脲支原体对左氧氟沙星、阿奇霉素、交沙霉素、罗红霉素、氧氟沙星、司帕沙星的敏感率均有下降趋势，敏感率降低13．0％～68．1％，且女性患者下降趋势更为明显；解脲脲支原体对左氧氟沙星、司帕沙星则随着年龄增长药物敏感率有明显下降趋势。结论解脲脲支原体对米诺环素、多西环素有很高的敏感性，不同性别、不同年龄患者解脲脲支原体的药物敏感率差异较大，经验用药应避免使用喹诺酮类药物，治疗时应根据药敏结果合理选用抗菌药物，以防止耐药菌株的增加和播散。
목적：분석환자비뇨생식도감염해뇨뇨지원체대항균약물적민감성，위림상합리사용항균약물제공의거。방법회고성분석2008년1월－2013년10월부산과、비뇨외과문진송검적해뇨뇨지원체배양양성3280례환자적림상자료급약민수거，채용WHONET진행통계분석。결과불동성별비뇨생식도감염환자해뇨뇨지원체대미낙배소、다서배소균유흔고적민감성，민감솔＞90．0％；2008－2013년해뇨뇨지원체대좌양불사성、아기매소、교사매소、라홍매소、양불사성、사파사성적민감솔균유하강추세，민감솔강저13．0％～68．1％，차녀성환자하강추세경위명현；해뇨뇨지원체대좌양불사성、사파사성칙수착년령증장약물민감솔유명현하강추세。결론해뇨뇨지원체대미낙배소、다서배소유흔고적민감성，불동성별、불동년령환자해뇨뇨지원체적약물민감솔차이교대，경험용약응피면사용규낙동류약물，치료시응근거약민결과합리선용항균약물，이방지내약균주적증가화파산。
OBJECTIVE To summarize the drug sensitivity of Mycoplasma urealytium in patients with genitourinar‐y tract infections from 2008 to 2013 ,so as to provide evidence for clinical rational use of antibacterials .METHODS The drug sensitivity and clinical data of M .urealytium in 3 280 patients with positive culture from the department of gynecology and the department of urinary surgery in the WHONET software database from Jan .2008 to Oct . 2013 were retrospectively analyzed .RESULTS M .urealytium in patients of different genders with urogenital tract infections had high sensitivity rates to minocycline and doxycycline ,with the sensitivity rate >90 .0% respective‐ly ,while the sensitivity rates to levofloxacin ,azithromycin ,josamycin ,roxithromycin ,ofloxacin ,sparfloxacin showed a downtrend respectively ,with sensitivity rates decreased by 13 .0% ~68 .1% ,and the downtrend was more obvious in female patients .The sensitivity rates of M .urealytium to levofloxacin and sparfloxacin showed a downtrend respectively along with the increase of age .CONCLUSION M .urealytium has high sensitivity rates to minocycline and doxycycline ,and there is an obvious difference in sensitivity rates of M .urealytium in patients of different genders and ages .Quinolones should be avoided in empirical treatment ,and clinical treatment should be based on the drug susceptibility test for reasonable selection of antibacterials so as to prevent the drug‐resistant strains from increasing and spreading .