CAJ | 학술논문

目的：探讨血管介入治疗患者预防性应用抗菌药物对其术后感染的影响，为临床治疗提供指导。方法选取2011年4月－2013年12月收治行介入治疗的患者280例，随机分为两组，对照组136例、观察组144例，对照组患者在介入治疗围手术期不预防性应用抗菌药物，观察组患者在术前给予头孢唑林预防性治疗，对两组患者体温升高、中性粒细胞增加、C‐反应蛋白升高及其切口感染、介入靶器官感染进行调查统计，采用SPSS13．0软件进行统计分析。结果观察组术后发热、中性粒细胞增加分别为40例占29．41％、8例占5．88％，对照组分别为46例占31．94％、10例占6．94％，两组患者均无C‐反应蛋白升高；观察组患者住院时间为（10．26 ± 0．81）d ，对照组为（7．50 ± 0．72）d ，上述比较两组差异均无统计学意义。结论预防性应用抗菌药物并不会降低血管介入治疗术后的感染概率，反而会增加患者费用，因此认为血管介入治疗无需预防性应用抗菌药物。
목적：탐토혈관개입치료환자예방성응용항균약물대기술후감염적영향，위림상치료제공지도。방법선취2011년4월－2013년12월수치행개입치료적환자280례，수궤분위량조，대조조136례、관찰조144례，대조조환자재개입치료위수술기불예방성응용항균약물，관찰조환자재술전급여두포서림예방성치료，대량조환자체온승고、중성립세포증가、C‐반응단백승고급기절구감염、개입파기관감염진행조사통계，채용SPSS13．0연건진행통계분석。결과관찰조술후발열、중성립세포증가분별위40례점29．41％、8례점5．88％，대조조분별위46례점31．94％、10례점6．94％，량조환자균무C‐반응단백승고；관찰조환자주원시간위（10．26 ± 0．81）d ，대조조위（7．50 ± 0．72）d ，상술비교량조차이균무통계학의의。결론예방성응용항균약물병불회강저혈관개입치료술후적감염개솔，반이회증가환자비용，인차인위혈관개입치료무수예방성응용항균약물。
OBJECTIVE To investigate the prophylactic antimicrobial effect on postoperative infection in patients receiving vascular intervention so as to provide guidance for clinical treatment .METHODS Totally 280 patients receiving interventional therapy in Apr .2011-Dec .2013 were enrolled and randomly divided into two groups ,the control group (n=136) and the observation group (n=144) .The control group did not take perioperative antimi‐crobial prophylaxis for interventional treatment ,while the observation group was given preoperative prophylactic cefazolin intravenously .The two groups of patients were investigated for increased body temperature ,increased neutrophils ,elevated C‐reactive protein ,incision infection and target organ infections .The software SPSS 13 .0 was used for statistical analysis .RESULTS Postoperative fever ,increased neutrophils occurred in 40 cases ac‐counting for 29 .41% ,and 8 cases (5 .88% ) respectively in the observation groups ,and 46 cases (31 .94% ) ,10 cases (6 .94% ) in the control group .Neither groups had increased C reactive protein .The hospitalization time was (10 .26 ± 0 .81) d in the observation group ,and (7 .50 ± 0 .72) d in the control group .The above comparison be‐tween the two groups was not significant .CONCLUSION Prophylactic antimicrobial drugs do not reduce the prob‐ability of postoperative infection in vascular interventional treatment ,which ,on the contrary ,will increase pa‐tients'costs .Therefore ,it is concluded that prophylactic antibiotics are unnecessary for vascular interventional treatment .