CAJ | 학술논문

目前研究表明，移植到梗死心肌的骨髓间充质干细胞（BM‐MSCs）有大量死亡，效果不理想。微小RNAs是一类非编码单链小分子RNA ，在许多方面参与BM‐MSCs移植治疗心肌梗死治疗过程。本文主要从微小RNAs生物学功能及对BM‐MSCs分化与旁分泌的调控作用方面，概述微小RNAs在BM‐MSCs移植治疗心肌梗死中的作用。
목전연구표명，이식도경사심기적골수간충질간세포（BM‐MSCs）유대량사망，효과불이상。미소RNAs시일류비편마단련소분자RNA ，재허다방면삼여BM‐MSCs이식치료심기경사치료과정。본문주요종미소RNAs생물학공능급대BM‐MSCs분화여방분비적조공작용방면，개술미소RNAs재BM‐MSCs이식치료심기경사중적작용。
Current researches indicate that transplanted BM‐MSCs accompanies massive death ,and its effect is unsat‐isfactory .The miRNAs are a class of small non‐coding single‐stranded RNA molecules ,involve therapeutic course of bone marrow mesenchymal stem cell treating myocardial infarction in many respects .The present article made an o‐verview on effect of microRNAs in transplanted BM‐MSCs treating myocardial infarction via mainly illustrating bio‐logical function of microRNAs and its regulation effect on BM‐MSCs differentiation and paracrine secretion .