临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
8期
672-674,675
,共4页
毛细支气管炎%呼吸道合胞病毒感染%孟鲁司特%喘息
毛細支氣管炎%呼吸道閤胞病毒感染%孟魯司特%喘息
모세지기관염%호흡도합포병독감염%맹로사특%천식
Bronchiolitis%Respiratory syncytial virus infection%Montelukast%Wheezing
目的：探讨孟鲁司特治疗呼吸道合胞病毒感染的毛细支气管炎的疗效及对气管炎症和再次喘息的影响。方法选择呼吸道合胞病毒感染的毛细支气管炎患儿120例随机分为观察组与对照组各60例，对照组给予镇咳、平喘、抗病毒等常规治疗，观察组在常规治疗的基础上再给予孟鲁司特维持治疗12周，比较两组患儿治疗有效率、喘息改善时间、平均住院时间，治疗前、后血清半胱氨酰白三烯（ CysLTs）、嗜酸粒细胞阳离子蛋白（ ECP）水平及再次喘息发生率。结果①观察组治疗有效率为100%，明显高于对照组的88.33%，差异有统计学意义（ P ﹤0.05）。②观察组喘息改善时间、平均住院时间较对照组短，差异有统计学意义（ P ﹤0.05）。③两组治疗后CysLTs、ECP水平较治疗前明显降低，观察组治疗后CysLTs、ECP水平较对照组降低明显，差异有统计学意义（均P ﹤0.05）；④观察组治疗12周再次喘息发生率为18.33%，明显低于对照组的33.33%，比较差异有统计学意义（ P ﹤0.05）。结论孟鲁司特治疗呼吸道合胞病毒感染性毛细支气管炎显效较快，可有效抑制气管炎症，减少喘息复发。
目的：探討孟魯司特治療呼吸道閤胞病毒感染的毛細支氣管炎的療效及對氣管炎癥和再次喘息的影響。方法選擇呼吸道閤胞病毒感染的毛細支氣管炎患兒120例隨機分為觀察組與對照組各60例，對照組給予鎮咳、平喘、抗病毒等常規治療，觀察組在常規治療的基礎上再給予孟魯司特維持治療12週，比較兩組患兒治療有效率、喘息改善時間、平均住院時間，治療前、後血清半胱氨酰白三烯（ CysLTs）、嗜痠粒細胞暘離子蛋白（ ECP）水平及再次喘息髮生率。結果①觀察組治療有效率為100%，明顯高于對照組的88.33%，差異有統計學意義（ P ﹤0.05）。②觀察組喘息改善時間、平均住院時間較對照組短，差異有統計學意義（ P ﹤0.05）。③兩組治療後CysLTs、ECP水平較治療前明顯降低，觀察組治療後CysLTs、ECP水平較對照組降低明顯，差異有統計學意義（均P ﹤0.05）；④觀察組治療12週再次喘息髮生率為18.33%，明顯低于對照組的33.33%，比較差異有統計學意義（ P ﹤0.05）。結論孟魯司特治療呼吸道閤胞病毒感染性毛細支氣管炎顯效較快，可有效抑製氣管炎癥，減少喘息複髮。
목적：탐토맹로사특치료호흡도합포병독감염적모세지기관염적료효급대기관염증화재차천식적영향。방법선택호흡도합포병독감염적모세지기관염환인120례수궤분위관찰조여대조조각60례，대조조급여진해、평천、항병독등상규치료，관찰조재상규치료적기출상재급여맹로사특유지치료12주，비교량조환인치료유효솔、천식개선시간、평균주원시간，치료전、후혈청반광안선백삼희（ CysLTs）、기산립세포양리자단백（ ECP）수평급재차천식발생솔。결과①관찰조치료유효솔위100%，명현고우대조조적88.33%，차이유통계학의의（ P ﹤0.05）。②관찰조천식개선시간、평균주원시간교대조조단，차이유통계학의의（ P ﹤0.05）。③량조치료후CysLTs、ECP수평교치료전명현강저，관찰조치료후CysLTs、ECP수평교대조조강저명현，차이유통계학의의（균P ﹤0.05）；④관찰조치료12주재차천식발생솔위18.33%，명현저우대조조적33.33%，비교차이유통계학의의（ P ﹤0.05）。결론맹로사특치료호흡도합포병독감염성모세지기관염현효교쾌，가유효억제기관염증，감소천식복발。
Objective To explore the efficacy and influence of montellukast on bronchitis symptoms and wheezing in treatment of bronchi-olitis caused by respiratory syncytial virus. Methods A total of 120 patients with bronchiolitis caused by respiratory syncytial virus were selected, and they were randomly divided into observation group and control group,60 cases in each group. Patients in control group were treated with con-ventional treatment including anti-coughing,anti-asthma,anti-virus,etc,patients in observation group were treated with montelukast mainte-nance treatment for 12 weeks on the basis of conventional therapy,efficiency,duration for improvement of asthma,average length of hospital stay, serum levels of cysteinyl leukotrienes( CysLTs)and eosinophil cationic protein( ECP)before and after the treatment and the recurrence rate of wheezing in two groups were compared. Results ①The efficiency of observation group was 100%,it was significantly higher than 88. 33% of control group,and the difference was statistically significant( P ﹤0. 05).②The duration for breath improvement and average length of hospital stay in patients of observation group were lower than those of control group,and the difference was statistically significant( P ﹤0. 05). ③Levels of CysLTs and ECP after treatment in observation group and control group were significantly lower than those before treatment,and levels of CysLTs and ECP in observation group after treatment were significantly lower than those of control group,and the difference was statistically significant( all P ﹤0. 05). ④The recurrence rate of wheezing after treatment for 12 weeks in observation group was 18. 33%,it was significantly lower than that (33. 33 %)of control group,and the difference was statistically significant( P ﹤0. 05). Conclusion The efficacy of montelukast in treatment of bronchiolitis caused by respiratory syncytial virus is markedly faster,it can effectively suppress the inflammation in airway and reduce the recur-rence of wheezing.
