临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
8期
664-666,667
,共4页
妊娠期糖尿病%子痫前期%脂质运载蛋白2 血脂%肾功能
妊娠期糖尿病%子癇前期%脂質運載蛋白2 血脂%腎功能
임신기당뇨병%자간전기%지질운재단백2 혈지%신공능
Gestational diabetes mellitus%Preeclampsia%Lipocalin 2%Blood lipid%Renal function
目的:通过检测妊娠期糖尿病(GDM)合并子痫前期(PE)患者血清中脂质运载蛋白2(LCN-2)的含量,探讨LCN-2在GDM合并PE中的检测水平及其与相关指标和病情的相关性。方法选取2011年1月至2014年6期间60例GDM合并PE患者为研究对象,60例患者中,30例为轻度PE患者( GDM合并轻度PE组),30例为重度PE患者( GDM合并重度PE组),选择30例单纯GDM患者和30例PE患者为疾病对照组,选择正常妊娠孕妇为正常对照组。检测受试者血尿酸( TG)、游离脂肪酸( FFAs)、尿酸( UA)、24 h尿蛋白、LCN-2水平及胰岛素抵抗指数( HOMA-IR),并对相关指标进行相关性分析。结果 GDM合并PE组FFAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平最高,差异有统计学意义( P ﹤0.01);正常妊娠组FAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平最低,差异有统计学意义( P ﹤0.01);GDM合并重度PE组FFAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平明显高于GDM合并轻度PE组,差异有统计学意义( P ﹤0.01);LCN-2与FFAs、HOMA-IR、TG、24 h尿蛋白和UA均呈正相关( P ﹤0.05),LCN-2与GDM合并PE严重程度呈正相关( P ﹤0.05)。结论 GDM合并PE患者血清LCN-2明显高表达,LCN-2的高表达与GDM合并PE患者的血脂代谢紊乱、胰岛素抵抗密切相关,LCN-2可作为预测GDM合并PE患者疾病严重程度及肾功能损害的指标。
目的:通過檢測妊娠期糖尿病(GDM)閤併子癇前期(PE)患者血清中脂質運載蛋白2(LCN-2)的含量,探討LCN-2在GDM閤併PE中的檢測水平及其與相關指標和病情的相關性。方法選取2011年1月至2014年6期間60例GDM閤併PE患者為研究對象,60例患者中,30例為輕度PE患者( GDM閤併輕度PE組),30例為重度PE患者( GDM閤併重度PE組),選擇30例單純GDM患者和30例PE患者為疾病對照組,選擇正常妊娠孕婦為正常對照組。檢測受試者血尿痠( TG)、遊離脂肪痠( FFAs)、尿痠( UA)、24 h尿蛋白、LCN-2水平及胰島素牴抗指數( HOMA-IR),併對相關指標進行相關性分析。結果 GDM閤併PE組FFAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平最高,差異有統計學意義( P ﹤0.01);正常妊娠組FAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平最低,差異有統計學意義( P ﹤0.01);GDM閤併重度PE組FFAs、HOMA-IR、TG、LCN-2、24 h尿蛋白和UA水平明顯高于GDM閤併輕度PE組,差異有統計學意義( P ﹤0.01);LCN-2與FFAs、HOMA-IR、TG、24 h尿蛋白和UA均呈正相關( P ﹤0.05),LCN-2與GDM閤併PE嚴重程度呈正相關( P ﹤0.05)。結論 GDM閤併PE患者血清LCN-2明顯高錶達,LCN-2的高錶達與GDM閤併PE患者的血脂代謝紊亂、胰島素牴抗密切相關,LCN-2可作為預測GDM閤併PE患者疾病嚴重程度及腎功能損害的指標。
목적:통과검측임신기당뇨병(GDM)합병자간전기(PE)환자혈청중지질운재단백2(LCN-2)적함량,탐토LCN-2재GDM합병PE중적검측수평급기여상관지표화병정적상관성。방법선취2011년1월지2014년6기간60례GDM합병PE환자위연구대상,60례환자중,30례위경도PE환자( GDM합병경도PE조),30례위중도PE환자( GDM합병중도PE조),선택30례단순GDM환자화30례PE환자위질병대조조,선택정상임신잉부위정상대조조。검측수시자혈뇨산( TG)、유리지방산( FFAs)、뇨산( UA)、24 h뇨단백、LCN-2수평급이도소저항지수( HOMA-IR),병대상관지표진행상관성분석。결과 GDM합병PE조FFAs、HOMA-IR、TG、LCN-2、24 h뇨단백화UA수평최고,차이유통계학의의( P ﹤0.01);정상임신조FAs、HOMA-IR、TG、LCN-2、24 h뇨단백화UA수평최저,차이유통계학의의( P ﹤0.01);GDM합병중도PE조FFAs、HOMA-IR、TG、LCN-2、24 h뇨단백화UA수평명현고우GDM합병경도PE조,차이유통계학의의( P ﹤0.01);LCN-2여FFAs、HOMA-IR、TG、24 h뇨단백화UA균정정상관( P ﹤0.05),LCN-2여GDM합병PE엄중정도정정상관( P ﹤0.05)。결론 GDM합병PE환자혈청LCN-2명현고표체,LCN-2적고표체여GDM합병PE환자적혈지대사문란、이도소저항밀절상관,LCN-2가작위예측GDM합병PE환자질병엄중정도급신공능손해적지표。
Objective To study expression of lipocalin-2 in diabetes mellitus complicated with preeclampsia patients and its relationship with the disease. Methods Between January 2011 and June 2014,60 patients with GDM combined with PE were selected as the research object, and of 60 cases of patients,30 cases of patients with mild PE( GDM with mild PE group),30 cases of patients with severe PE( GDM group with severe PE),30 cases of simple GDM patients and 30 patients with PE were selected as disease control. Normal pregnancy pregnant women were selected as normal control group. Test subjectsˊblood uric acid( TG),free fatty acids( FFAs),uric acid( UA),24 hours urinary protein,LCN-2( HOMA IR)level and insulin resistance index,correlation analysis and the related indicators were tested. Results GDM combined with PE group FFAs,HOMA-IR,TG,LCN-2,24 h urine protein UA levels were the highest. And the difference was statistically significant( P ﹤0. 01)and normal pregnancy group FFAs,HOMA-IR,TG,LCN 2,24 h urine protein and UA levels were lowest. The difference was statistically significant( P ﹤0. 01). The FFAs,HOMA IR,TG,LCN 2,24 h urine protein and UA levels of GDM group with severe PE were significantly higher than GDM group with mild PE group. The difference was statistically significant( P ﹤0. 01). There were positive correlations between LCN-2 with FFAs,HOMA-IR,TG,24 h urine protein and UA( P ﹤0. 05),and there were positive correlations between LCN-2 and GDM group with PE severity( P ﹤0. 05). Conclusion GDM complicated with PE patientsˊserum LCN-2 was of significantly high expression. The high expression of LCN-2 closely related with lipid metabolic disorder and insulin resistance in GDM combined with PE,and LCN-2 can be used as index of the severity of disease and renal impairment of patients with GDM combined with PE.