CAJ | 학술논문

目的：探讨卵巢癌患者血浆D－二聚体、纤维蛋白原（FIB）、白细胞介素6（IL－6）动态变化及其对卵巢癌诊断中的价值和临床意义。方法：选择卵巢癌患者65例、35例卵巢良性肿瘤患者和30例健康体检者做对照，取卵巢癌患者和对照组的血清及血浆，用胶乳凝集法测定血浆中的D－二聚体、FIB含量，用ELISA法测定IL－6水平。结果：卵巢癌患者FIB、IL－6、D－二聚体水平明显高于对照组和卵巢良性肿瘤组，差异有显著统计学意义（P＜0．05）；卵巢良性肿瘤患者FIB、IL－6、D－二聚体水平与正常对照组无显著差异（P＞0．05），癌症组FIB、IL－6、D－二聚体随着临床分期的升高而递增，相关性分析表明，FIB与IL－6、D－二聚体呈正相关（ r＝0．31，r＝0．56）。结论：FIB、IL－6、D－二聚体联合检测对于卵巢癌的早期诊断、分期及判断预后具有重要的临床价值。
목적：탐토란소암환자혈장D－이취체、섬유단백원（FIB）、백세포개소6（IL－6）동태변화급기대란소암진단중적개치화림상의의。방법：선택란소암환자65례、35례란소량성종류환자화30례건강체검자주대조，취란소암환자화대조조적혈청급혈장，용효유응집법측정혈장중적D－이취체、FIB함량，용ELISA법측정IL－6수평。결과：란소암환자FIB、IL－6、D－이취체수평명현고우대조조화란소량성종류조，차이유현저통계학의의（P＜0．05）；란소량성종류환자FIB、IL－6、D－이취체수평여정상대조조무현저차이（P＞0．05），암증조FIB、IL－6、D－이취체수착림상분기적승고이체증，상관성분석표명，FIB여IL－6、D－이취체정정상관（ r＝0．31，r＝0．56）。결론：FIB、IL－6、D－이취체연합검측대우란소암적조기진단、분기급판단예후구유중요적림상개치。
Objective:To determine the level of FIB,IL-6,D-dimer and explore the differential diagnostic value and clinical significance of the tumor markers in patients with ovarian cancers.Methods: The level in serum of 65 ovarian cancer and 35 benign tumor of ovarian and 30 controls FIB and D-dimer were measured by latex agglutination assay.The IL-6 levels were measured by ELISA method.Results:Compared with the normal controls and benign tumor of ovarian cancer, there were some significantly changes in ovarian cancer patients including FIB,IL-6,D-dimer increased (P<0.05),there was no significant differences in FIB,D-dimer levels between ovarian benign tumors and normal controls(P>0.05).Companied with TNM stage increased,the levels of FIB,IL-6,D-dimer ovarian cancer groups increased.The correlation analysis showed that FIB was positively correlated with D-dimer and IL-6 (r=0.56,r=0.31).Conclusion:The level of serum FIB,D-dimer,IL-6 detection in patients with ovarian cancer are helpful in early diagnosis, dicision of clinical stages and regimen prognosis.