CAJ | 학술논문

目的：探讨血流感染鲍氏不动杆菌的临床分布及耐药性，为指导临床合理用药和控制医院感染提供参考依据。方法回顾性分析2008年1月－2012年12月医院105例发生鲍氏不动杆菌血流感染患者的临床分布及其耐药性，采用WHONET5．4进行统计分析。结果5年来共有105例患者发生鲍氏不动杆菌血流感染，且发生鲍氏不动杆菌血流感染患者的人数逐年上升；科室分布以外科重症监护病房和肝胆外科为主，分别占37．14％、16．19％；分析103例发生鲍氏不动杆菌血流感染患者的血培养结果发现，多耐药鲍氏不动杆菌共84株占81．6％；其对13种抗菌药物的耐药率以头孢哌酮／舒巴坦最低，为35．9％，对其他常用抗菌药物的耐药率均＞75．0％。结论发生血流感染的鲍氏不动杆菌多为多药耐药菌，其对常用抗菌药物的耐药性均较强，对怀疑有鲍氏不动杆菌血流感染的患者可经验性选用头孢哌酮／舒巴坦。
목적：탐토혈류감염포씨불동간균적림상분포급내약성，위지도림상합리용약화공제의원감염제공삼고의거。방법회고성분석2008년1월－2012년12월의원105례발생포씨불동간균혈류감염환자적림상분포급기내약성，채용WHONET5．4진행통계분석。결과5년래공유105례환자발생포씨불동간균혈류감염，차발생포씨불동간균혈류감염환자적인수축년상승；과실분포이외과중증감호병방화간담외과위주，분별점37．14％、16．19％；분석103례발생포씨불동간균혈류감염환자적혈배양결과발현，다내약포씨불동간균공84주점81．6％；기대13충항균약물적내약솔이두포고동／서파탄최저，위35．9％，대기타상용항균약물적내약솔균＞75．0％。결론발생혈류감염적포씨불동간균다위다약내약균，기대상용항균약물적내약성균교강，대부의유포씨불동간균혈류감염적환자가경험성선용두포고동／서파탄。
OBJECTIVE To investigate the characteristics of distribution of Acinetobacter baumannii causing blood‐stream infections and explore its drug resistance to the commonly used antibiotics so as to provide basis for reason‐able use of antibiotics and control of hospital infections .METHODS The characteristics of distribution and drug re‐sistance of A .baumannii isolated from inpatients with bloodstream infections from Jan .2008 to Dec .2012 were analyzed retrospectively .The software WHONET5 .4 was used for statistical analysis .RESULTS Totally 105 in‐patients were identified to have A .baumannii bloodstream infections in the five years and the number of infected patients increased by years .Most infected patients were from the surgical ICU (37 .14% ) and the department of hepatobiliary surgery (16 .19% ) .Of all the 103 cases of blood culture results ,84 (81 .6% ) strains of multi‐drug resistance were identified . The resistance rate to cefoperazone/sulbactam was the lowest (the resistance rate 35 .9% ) among 13 kinds of antibiotics .And the resistance rates of these blood isolates to other 12 kinds of antibi‐otics were all higher than 75% .CONCLUSION Most A .baumannii strains causing bloodstream infections were multi‐drug resistant and their resistance rate to the commonly used antibiotics was high .And cefoperazone/sulbac‐tam can be chosen empirically to treat patients who are suspected to have A .baumannii bloodstream infections .