中华医院感染学杂志
中華醫院感染學雜誌
중화의원감염학잡지
Chinese Journal of Nosocomiology
2015年
7期
1467-1469
,共3页
血清降钙素原%重症监护病房%多药耐药菌%感染%抗菌药物
血清降鈣素原%重癥鑑護病房%多藥耐藥菌%感染%抗菌藥物
혈청강개소원%중증감호병방%다약내약균%감염%항균약물
Serum procalcitonin%ICU%M ulti-drug resistant bacteria%Infections%Antimicrobial agents
目的：研究IC U多药耐药感染患者应用血清降钙素原（PC T ）检测方法，以指导IC U多药耐药感染患者抗菌药物治疗的作用及意义。方法选取2013年1月－2014年1月确诊为IC U多药耐药感染的102例患者进行研究分析，随机分为对照组与观察组，各51例；对比两组患者抗菌药物使用时间、使用剂量及炎性反应进行分析，采用SPSS16．0软件进行统计分析。结果抗菌药物使用时间观察组（6．6±1．2）d、较对照组的（9．8±1．9）d少，且不同时间内抗菌药物的使用率较对照组明显减少；炎性水平指标显示观察组的PC T 水平（32．6 ± 9．6）ng／L低于对照组的（98．5±21．4）ng／L ，对照组CRP（11．5±4．1）μg／L明显高于观察组的（5．4 ± 2．2）μg／L ，白细胞计数观察组（15．5±3．7）×109／L同样低于对照组（32．4±5．2）×109／L，差异有统计学意义（P＜0．05）。结论对IC U多药耐药菌感染抗菌药物应用中PC T检测可有效降低抗菌药物的使用量，缓解了医患的内外在压力。
目的：研究IC U多藥耐藥感染患者應用血清降鈣素原（PC T ）檢測方法，以指導IC U多藥耐藥感染患者抗菌藥物治療的作用及意義。方法選取2013年1月－2014年1月確診為IC U多藥耐藥感染的102例患者進行研究分析，隨機分為對照組與觀察組，各51例；對比兩組患者抗菌藥物使用時間、使用劑量及炎性反應進行分析，採用SPSS16．0軟件進行統計分析。結果抗菌藥物使用時間觀察組（6．6±1．2）d、較對照組的（9．8±1．9）d少，且不同時間內抗菌藥物的使用率較對照組明顯減少；炎性水平指標顯示觀察組的PC T 水平（32．6 ± 9．6）ng／L低于對照組的（98．5±21．4）ng／L ，對照組CRP（11．5±4．1）μg／L明顯高于觀察組的（5．4 ± 2．2）μg／L ，白細胞計數觀察組（15．5±3．7）×109／L同樣低于對照組（32．4±5．2）×109／L，差異有統計學意義（P＜0．05）。結論對IC U多藥耐藥菌感染抗菌藥物應用中PC T檢測可有效降低抗菌藥物的使用量，緩解瞭醫患的內外在壓力。
목적：연구IC U다약내약감염환자응용혈청강개소원（PC T ）검측방법，이지도IC U다약내약감염환자항균약물치료적작용급의의。방법선취2013년1월－2014년1월학진위IC U다약내약감염적102례환자진행연구분석，수궤분위대조조여관찰조，각51례；대비량조환자항균약물사용시간、사용제량급염성반응진행분석，채용SPSS16．0연건진행통계분석。결과항균약물사용시간관찰조（6．6±1．2）d、교대조조적（9．8±1．9）d소，차불동시간내항균약물적사용솔교대조조명현감소；염성수평지표현시관찰조적PC T 수평（32．6 ± 9．6）ng／L저우대조조적（98．5±21．4）ng／L ，대조조CRP（11．5±4．1）μg／L명현고우관찰조적（5．4 ± 2．2）μg／L ，백세포계수관찰조（15．5±3．7）×109／L동양저우대조조（32．4±5．2）×109／L，차이유통계학의의（P＜0．05）。결론대IC U다약내약균감염항균약물응용중PC T검측가유효강저항균약물적사용량，완해료의환적내외재압력。
OBJECTIVE To investigate the methods of serum procalcitonin detection in the treatment of patients in‐fected by multi‐drug resistant organisms so as to guide the therapy of antibiotics in those patients .METHODS From Jan .2013 to Jan .2014 ,totally 102 cases of patients infected by multi‐drug resistant organisms in ICU were randomly divided into control group and observation group with 51 cases each .The using time ,dosage and inflam‐matory response of the antibiotics used by the two groups of patients were compared and analyzed .All data were statistically analyzed by SPSS 16 .0 software .RESULTS The use time of antimicrobial agents in the observation group was (6 .6 ± 1 .2) d ,which was less than the control group of (9 .8 ± 1 .9) d ,and the usage rate of antibiot‐ics at different time in the observation group decreased obviously compared with the control group .And the in‐flammatory indicator showed that PCT level in the observation group was (32 .6 ± 9 .6) ng/L ,which was lower than the control group of (98 .5 ± 21 .4) ng/L .The CRP in the control group was (11 .5 ± 4 .1)μg/L ,significant‐ly higher than that of the observation group of (5 .4 ± 2 .2)μg/L .The white blood cell count in the observation group was (15 .5 ± 3 .7) × 109/L ,which was also lower than the control group with (32 .4 ± 5 .2) × 109/L .The difference was significant (P<0 .05) .CONCLUSION Application of serum procalcitonin in detecting antibiotic re‐sistance to multi‐drugs in ICU can effectively reduce the amount of use of antimicrobial drugs so as to ease the pressure inside and outside the doctor‐patient relations .
