CAJ | 학술논문

目的：分析服用抗精神病药物并发肺部感染患者的临床特点及影响因素，为临床治疗提供参考依据。方法对2012年8月－2013年10月80例服用抗精神病药物并发肺部感染患者的临床资料进行回顾性分析，对感染类型、各型肺部感染的血常规特点、对症治疗时间进行对比，同时分析导致肺部感染的危险因素，采用SPSS 19．0软件进行统计分析。结果细菌性肺炎及吸入性肺炎发病率较高，其次为支原体肺炎，其他类型肺炎较为少见；细菌性肺炎、吸入性肺炎及支原体肺炎患者中性粒细胞百分比均明显高于其他类型肺炎组患者（F＝16．6134，P＝0．0012），同时三者比较差异无统计学意义；吸入性肺炎治疗时间最长，其次为细菌性肺炎，其他类型肺部感染比较差异无统计学意义；经单因素及 logistic多因素分析显示，年龄＞42岁、白蛋白＜40 g／L、血钾＜3．5 mmol／L及NIHSS＞35分为肺部感染发生的危险因素（P＜0．05）。结论抗精神病药物并发肺部感染类型存在差异，临床治疗应注意对症治疗，同时也应注意年龄、营养摄入、血钾程度及NIHSS评分对肺内感染发生的影响。
목적：분석복용항정신병약물병발폐부감염환자적림상특점급영향인소，위림상치료제공삼고의거。방법대2012년8월－2013년10월80례복용항정신병약물병발폐부감염환자적림상자료진행회고성분석，대감염류형、각형폐부감염적혈상규특점、대증치료시간진행대비，동시분석도치폐부감염적위험인소，채용SPSS 19．0연건진행통계분석。결과세균성폐염급흡입성폐염발병솔교고，기차위지원체폐염，기타류형폐염교위소견；세균성폐염、흡입성폐염급지원체폐염환자중성립세포백분비균명현고우기타류형폐염조환자（F＝16．6134，P＝0．0012），동시삼자비교차이무통계학의의；흡입성폐염치료시간최장，기차위세균성폐염，기타류형폐부감염비교차이무통계학의의；경단인소급 logistic다인소분석현시，년령＞42세、백단백＜40 g／L、혈갑＜3．5 mmol／L급NIHSS＞35분위폐부감염발생적위험인소（P＜0．05）。결론항정신병약물병발폐부감염류형존재차이，림상치료응주의대증치료，동시야응주의년령、영양섭입、혈갑정도급NIHSS평분대폐내감염발생적영향。
OBJECTIVE To analyze clinical characteristics and influencing factors for pulmonary infections in pa‐tients receiving antipsychotic medication so as to provide reference for clinical treatment .METHODS Clinical data were retrospectively analyzed of 80 cases of antipsychotic medication complicated with pulmonary infections during Aug .2012 to Oct .2013 .Characteristics of blood routine and symptomatic treatment time were compared by types of pulmonary infections ,meanwhile ,risk factors for pulmonary infections were analyzed .The software SPSS19 .0 was used for statistical analysis .RESULTS The incidence of bacterial pneumonia and aspiration pneumonia was rel‐atively high ,followed by Mycoplasma pneumonia ,while the other types of pneumonia were rare .White blood cell count in routine blood test was significantly higher in the patients with bacterial pneumonia and aspiration pneumo‐nia than in those with other types of pneumonia (F=21 .4131 ,P=0 .0001) ,while the comparison between pa‐tients with the former three types was not significant .The treatment time for aspiration pneumonia was the lon‐gest ,followed by bacterial pneumonia and the comparison to other types of pulmonary infections was not signifi‐cant .The univariate and multivariate logistic analyse showed that age>42 years ,albumin<40g/L ,serum potas‐sium<3 .5mmol/L and NIHSS> 35 were risk factors for pulmonary infections (P< 0 .05) .CONCLUSION As types of pulmonary infections induced by antipsychotic medication vary ,clinicians should pay attention to symp‐tomatic treatment as well as effects of age ,nutrition intake ,serum potassium level and NIHSS on pulmonary in‐fections .