中国执业药师
中國執業藥師
중국집업약사
CHINA LICENSED PHARMACIST
2015年
5期
52-56
,共5页
严重药品不良反应%国家药品不良反应监测系统%报告
嚴重藥品不良反應%國傢藥品不良反應鑑測繫統%報告
엄중약품불량반응%국가약품불량반응감측계통%보고
Serious Adverse Drug Reaction%National Adverse Drug Reaction Monitoring System%Report
目的：了解严重药品不良反应（ADR）的发生特点，为ADR监测工作提供参考。方法：提取国家ADR监测系统中2011-2013年孝感市上报的ADR严重病例报告171份，对报告来源、患者性别、药品种类、给药途径、ADR累及器官/系统等进行分析。结果：严重ADR报告率与年龄因素和性别因素有关，且儿童和老年人高于中青年人（P ＜0.05），女性高于男性（男女之比为1∶1.44， P ＜0.05）；171份严重 ADR 报告中，抗感染药（78，45.62%）、维生素、营养药、调节水电解质和酸碱平衡药（37，21.64%）和中药注射剂（15，8.77%）位居前三；静脉滴注给药125例（73.09%），口服给药26例（15.20%）；过敏性反应82例（47.95%），皮肤及附件损害36例（21.05%）。结论：2011-2013年孝感市严重ADR高发于女性、儿童和老年人用药、抗感染药物和静脉滴注给药，在ADR监测中应引起注意。
目的：瞭解嚴重藥品不良反應（ADR）的髮生特點，為ADR鑑測工作提供參攷。方法：提取國傢ADR鑑測繫統中2011-2013年孝感市上報的ADR嚴重病例報告171份，對報告來源、患者性彆、藥品種類、給藥途徑、ADR纍及器官/繫統等進行分析。結果：嚴重ADR報告率與年齡因素和性彆因素有關，且兒童和老年人高于中青年人（P ＜0.05），女性高于男性（男女之比為1∶1.44， P ＜0.05）；171份嚴重 ADR 報告中，抗感染藥（78，45.62%）、維生素、營養藥、調節水電解質和痠堿平衡藥（37，21.64%）和中藥註射劑（15，8.77%）位居前三；靜脈滴註給藥125例（73.09%），口服給藥26例（15.20%）；過敏性反應82例（47.95%），皮膚及附件損害36例（21.05%）。結論：2011-2013年孝感市嚴重ADR高髮于女性、兒童和老年人用藥、抗感染藥物和靜脈滴註給藥，在ADR鑑測中應引起註意。
목적：료해엄중약품불량반응（ADR）적발생특점，위ADR감측공작제공삼고。방법：제취국가ADR감측계통중2011-2013년효감시상보적ADR엄중병례보고171빈，대보고래원、환자성별、약품충류、급약도경、ADR루급기관/계통등진행분석。결과：엄중ADR보고솔여년령인소화성별인소유관，차인동화노년인고우중청년인（P ＜0.05），녀성고우남성（남녀지비위1∶1.44， P ＜0.05）；171빈엄중 ADR 보고중，항감염약（78，45.62%）、유생소、영양약、조절수전해질화산감평형약（37，21.64%）화중약주사제（15，8.77%）위거전삼；정맥적주급약125례（73.09%），구복급약26례（15.20%）；과민성반응82례（47.95%），피부급부건손해36례（21.05%）。결론：2011-2013년효감시엄중ADR고발우녀성、인동화노년인용약、항감염약물화정맥적주급약，재ADR감측중응인기주의。
ABSTRACTObjective:To investigate the characteristics of serious adverse drug reactions(ADRs)so as to pro-vide a reference for ADR monitoring.Methods:The reports of 171 cases of severe ADRs submitted by Xiaogan city from 2011 to 2013 were extracted from the National Adverse Drug Reaction Monitoring System. The data was analyzed such as the source of report, patient sex, drug species, route of administration and ADR involving or-gans/systems.Results:The serious ADR reporting rate was associated with age and gender factors, serious ADRs in children and the elderly were higher than young and middle-aged people(P<0.05)and higher in women than in men(the ratio of male to female was 1∶1.44,P<0.05). In 171 cases of severe ADRs, 78 cases(45.62%) ever used anti-infective drugs, 37 cases(21.64%)used Vitamins, nutritional supplements and the drugs of regulat-ing water-electrolyte and acid-base balance, and 15 cases(8.77%)were given traditional Chinese medicine injec-tions. About 125 cases(73.09%)received intravenous dripping and 26 cases(15.20%)took medicines by oral ad-ministration. Allergic reactions occurred in 82 cases(47.95%)and 36 cases(21.05%)got skin and appendages disorder.Conclusion:The high incidence of serious ADRs in Xiaogan city from 2011 to 2013 occurred in women, children and elder people after taking medicines, and mostly induced by anti-infective drugs and by intravenous ad-ministration. More attention should be paid to serious ADR monitoring.
