CAJ | 학술논문

目的：探讨普拉洛芬滴眼液对干眼症治疗的效果。方法选取2011年2月—2013年12月收治确诊为干眼症的患者80例,随机分为观察组、对照组,每组40例。对照组患者给予人工泪液治疗,观察组给予普拉洛芬滴眼液,治疗第1、2、3、4周,观察患者症状及检查结果变化。结果两组治疗3、4周后与治疗前比较,Schirmer I 试验结果、泪液破裂时间显著延长(P <0．05),荧光染色实验评分、问卷调查分数显著降低(P <0．05)。治疗2、3、4周观察组泪膜破裂时间显著长于对照组,荧光素染色实验评分与干眼症状问卷结果均显著低于对照组(P <0．05)。治疗第4周,观察组总有效率显著高于对照组(P <0．05)。结论普拉洛芬在干眼症治疗中,较人工泪液疗效显著。
목적：탐토보랍락분적안액대간안증치료적효과。방법선취2011년2월—2013년12월수치학진위간안증적환자80례,수궤분위관찰조、대조조,매조40례。대조조환자급여인공루액치료,관찰조급여보랍락분적안액,치료제1、2、3、4주,관찰환자증상급검사결과변화。결과량조치료3、4주후여치료전비교,Schirmer I 시험결과、루액파렬시간현저연장(P <0．05),형광염색실험평분、문권조사분수현저강저(P <0．05)。치료2、3、4주관찰조루막파렬시간현저장우대조조,형광소염색실험평분여간안증상문권결과균현저저우대조조(P <0．05)。치료제4주,관찰조총유효솔현저고우대조조(P <0．05)。결론보랍락분재간안증치료중,교인공루액료효현저。
Objective To investigate the effectiveness of Pranoprofen Eye Drops in treatment of patients with dry eye syndromes. Methods A total of 80 patients with dry eye syndromes admitted during February 2011 and December 2013 were randomly divided into observation group (n = 40) and control group (n = 40). The control group was treated with artificial tears, while the observation group was treated with Pranoprofen Eye Drops. The symptoms and changes of ex-amination results of patients were observed during the 1st , 2nd , 3rd and 4th week of treatment. Results During the 3rd and 4th week of treatment, Schirmer I test results were significantly lengthened and tears ruptured times were significantly pro-longed compared with those before treatment (P < 0. 05), and the scores of fluorescence staining test and questionnaire were significantly lower than those before treatment in the two groups (P <0. 05). During the 2nd , 3rd and 4th week of treat-ment in observation group, breakup time of tear film was significantly longer, while the scores of fluorescence staining test and questionnaire were significantly lower than those the control group (P <0. 05). After 4 weeks of treatment, the total ef-fective rate of observation group was significantly higher than that of control group (P < 0. 05). Conclusion The Prano-profen Eye Drops in treatment of dry eye syndromes may achieve better effect than that by artificial tears therapy.