CAJ | 학술논문

目的：探讨超声诊断慢性乙型肝炎（CHB）患者代偿期肝硬化的价值。方法2010年1月至2015年1月行肝活组织检查的 CHB 患者226例，收集患者 B 型超声资料，利用 Logistic 回归分析与代偿期肝硬化程度相关的指标，采用受试者工作特征曲线下面积（AUROC）评价 B 型超声诊断代偿期肝硬化的价值。结果超声指标中 SWV、门静脉主干内径、胆囊壁厚度、脾脏长径、脾脏厚度、脾脏面积、脾静脉内径、门静脉最大流速共8项指标与肝脏炎症分级和纤维化分期均相关。其中，SWV、门静脉主干内径、脾脏长径、门静脉最大流速、脾静脉内径与组织学代偿期肝硬化独立相关，AUC 均＞0.7。结论超声的部分影像学指标对预测组织学代偿期肝硬化有潜在的价值。
목적：탐토초성진단만성을형간염（CHB）환자대상기간경화적개치。방법2010년1월지2015년1월행간활조직검사적 CHB 환자226례，수집환자 B 형초성자료，이용 Logistic 회귀분석여대상기간경화정도상관적지표，채용수시자공작특정곡선하면적（AUROC）평개 B 형초성진단대상기간경화적개치。결과초성지표중 SWV、문정맥주간내경、담낭벽후도、비장장경、비장후도、비장면적、비정맥내경、문정맥최대류속공8항지표여간장염증분급화섬유화분기균상관。기중，SWV、문정맥주간내경、비장장경、문정맥최대류속、비정맥내경여조직학대상기간경화독립상관，AUC 균＞0.7。결론초성적부분영상학지표대예측조직학대상기간경화유잠재적개치。
Objective To investigate the application of color Doppler ultrasound in diagnosis of early liver cirrhosis (S4)for patients with chronic hepatitis B (CHB).Methods Ultrasound examinations of 226 CHB patients,which received liver biopsy in Putuo Hospital of Shanghai from January 2010 to January 2015,were collected.Logistic regression analysis was performed to determine factors independently correlated with early liver cirrhosis.Diagnostic value of ultrasound index was assessed by area under receiver operating characteristic curve (AUROC).Results Eight indicators obtained from ultrasound (shear wave velocity,diameter of main portal vein,gallbladder wall thickness, spleen diameter, spleen thickness,splenic square area,inner diameter of splenic vein,maximum velocity of portal vein)were correlated with liver inflammation grades and fibrosis stages,respectively.Logistic regression analysis indicated that shear wave velocity, diameter of main portal vein,spleen diameter,portal venous velocity and inner diameter of splenic vein in ultrasound findings were independently correlated with early liver cirrhosis.AUROC was more than 0.7 in each indicators.Conclusion There is a potential value for some indicators from ultrasound in predicting early cirrhosis.