CAJ | 학술논문

目的：对恩替卡韦联合长效干扰素治疗乙肝的临床效果进行研究。方法选取于2013年10月～2014年6月期间在我院接受治疗的44例乙肝患者并随机分为两组，对照组患者给予恩替卡韦治疗，治疗组患者给予恩替卡韦联合长效干扰素治疗，对两种治疗方法的临床效果进行对比。结果治疗组患者的治疗总有效率、HBeAg转阴率和HBV-DNA转阴率均显著高于对照组，不良反应发生率显著低于对照组，差异显著，有统计学意义（P<0.05）。结论对乙肝患者采用恩替卡韦联合长效干扰素治疗具有显著的临床治疗效果，并且能够大大的降低不良反应发生情况，值得在临床治疗乙肝中广泛应用。
목적：대은체잡위연합장효간우소치료을간적림상효과진행연구。방법선취우2013년10월～2014년6월기간재아원접수치료적44례을간환자병수궤분위량조，대조조환자급여은체잡위치료，치료조환자급여은체잡위연합장효간우소치료，대량충치료방법적림상효과진행대비。결과치료조환자적치료총유효솔、HBeAg전음솔화HBV-DNA전음솔균현저고우대조조，불량반응발생솔현저저우대조조，차이현저，유통계학의의（P<0.05）。결론대을간환자채용은체잡위연합장효간우소치료구유현저적림상치료효과，병차능구대대적강저불량반응발생정황，치득재림상치료을간중엄범응용。
Objectives Clinical effect of entecavir medication combined with pegylated interferon in treatment of Hepatitis B is to be studied. Methods Choose 44 patients of hepatitis B who are received and treated in hospital from October 2013 to June 2014 and separate them into two groups at random. Patients in control group are given entecavir medication treatment,while patients in study group are given entecavir medication combined with pegylated interferon treatment,and then observe and compare treatment effects between two groups. Results Patients’treatment efficacy,negative conversion rate of HBeAg and HBV-DNA in study group are much higher than counterparts in control group; besides,side-effect incidence in study group is less; there is a treatment differential between two groups,and such a differential has statistic value(P<0.05).Conclusion Entecavir medication combined with pegylated interferon is of efficacy in treatment of Hepatitis B;it is conducive to decreasing side-effect incidence significantly;thus,such a medication treatment is quite worthwhile to be promoted and applied clinical y in treatment of Hepatitis B.