中华医院感染学杂志
中華醫院感染學雜誌
중화의원감염학잡지
Chinese Journal of Nosocomiology
2015年
7期
1501-1503
,共3页
呼吸内科%肺部感染%革兰阴性菌%耐药性
呼吸內科%肺部感染%革蘭陰性菌%耐藥性
호흡내과%폐부감염%혁란음성균%내약성
Department of respiratory medicine%Pulmonary infection%Gram-negative bacteria%Drug resistance
目的：调查呼吸内科住院患者肺部革兰阴性菌耐药趋势，指导抗菌药物合理使用，为临床治疗提供参考依据。方法统计分析2011年7月1日－2013年6月30日呼吸内科病房肺部感染患者标本中共检出1885株病原菌，分析革兰阴性菌的分布及耐药监测结果，采用SPSS17．0软件进行统计处理。结果分离革兰阴性菌980株，占52．0％，其中铜绿假单胞菌居于首位，占24．4％；革兰阴性菌对临床常用抗菌药物表现为严重耐药和多药耐药；碳青酶烯类、哌拉西林／他唑巴坦除对嗜麦芽寡养单胞菌外的临床感染常见革兰阴性菌保持较高抗菌活性，大肠埃希菌和肺炎克雷伯菌产超广谱β‐内酰胺酶（ESBLs）检出率分别为81．3％和44．7％。结论呼吸内科住院患者肺部感染以革兰阴性菌感染为主，革兰阴性菌耐药率高，加强耐药性监测、合理使用抗菌药物十分重要。
目的：調查呼吸內科住院患者肺部革蘭陰性菌耐藥趨勢，指導抗菌藥物閤理使用，為臨床治療提供參攷依據。方法統計分析2011年7月1日－2013年6月30日呼吸內科病房肺部感染患者標本中共檢齣1885株病原菌，分析革蘭陰性菌的分佈及耐藥鑑測結果，採用SPSS17．0軟件進行統計處理。結果分離革蘭陰性菌980株，佔52．0％，其中銅綠假單胞菌居于首位，佔24．4％；革蘭陰性菌對臨床常用抗菌藥物錶現為嚴重耐藥和多藥耐藥；碳青酶烯類、哌拉西林／他唑巴坦除對嗜麥芽寡養單胞菌外的臨床感染常見革蘭陰性菌保持較高抗菌活性，大腸埃希菌和肺炎剋雷伯菌產超廣譜β‐內酰胺酶（ESBLs）檢齣率分彆為81．3％和44．7％。結論呼吸內科住院患者肺部感染以革蘭陰性菌感染為主，革蘭陰性菌耐藥率高，加彊耐藥性鑑測、閤理使用抗菌藥物十分重要。
목적：조사호흡내과주원환자폐부혁란음성균내약추세，지도항균약물합리사용，위림상치료제공삼고의거。방법통계분석2011년7월1일－2013년6월30일호흡내과병방폐부감염환자표본중공검출1885주병원균，분석혁란음성균적분포급내약감측결과，채용SPSS17．0연건진행통계처리。결과분리혁란음성균980주，점52．0％，기중동록가단포균거우수위，점24．4％；혁란음성균대림상상용항균약물표현위엄중내약화다약내약；탄청매희류、고랍서림／타서파탄제대기맥아과양단포균외적림상감염상견혁란음성균보지교고항균활성，대장애희균화폐염극뢰백균산초엄보β‐내선알매（ESBLs）검출솔분별위81．3％화44．7％。결론호흡내과주원환자폐부감염이혁란음성균감염위주，혁란음성균내약솔고，가강내약성감측、합리사용항균약물십분중요。
OBJECTIVE To investigate the antibiotic resistance of gram‐negative bacteria in patients with pulmonary infections in the department of respiratory medicine ,so as to guide clinical medication .METHODS Totally 1885 strains of pathogens were detected from the samples of patients with pulmonary infections in the department of re‐spiratory medicine from Jul .2011 to Jul .2013 .The samples were statistically counted to analyze the distribution of gram‐negative bacteria and the results of drug resistance monitoring .All data were analyzed by SPSS 17 .0 soft‐ware .RESULTS A total of 980 strains of gram‐negative bacteria were isolated ,accounting for 52 .0% .The most common pathogens of gram‐negative bacteria were Pseudomonas aeruginosa ,accounting for 24 .4% .Mainly gram‐negative bacteria were severe and multi‐resistant to some clinical common used antibiotics .Carbopenems and pip‐eracillin/tazobactam were the most active antibiotics to most gram‐negative bacteria .The detection rates of ESBLs producing strains of E .coli and K .pneumoniae were 81 .3% and 44 .7% respectively .CONCLUSION Pulmonary infections of patients in the department of respiratory medicine are mainly caused by gram‐negative bacteria with high rate of drug resistance .It′s important and urgent to strengthen surveillance of bacterial resistance and control for appropriate using of antibiotics .
