CAJ | 학술논문

目的：探讨血清超敏C反应蛋白（hs-CRP）、胱抑素C（Cys C）和尿β2-微球蛋白（β2-MG）联合检测在妊娠糖尿病（GDM）肾病诊断中的临床应用价值。方法：89例GDM患者和110例健康孕妇为研究对象。在清晨抽取3ml空腹静脉血，经离心后得到血清。同时收集24h尿液。采用全自动生化分析仪检测血清尿酸、尿素、肌酐、hs-CRP和Cys C；用免疫比浊法检测尿β2-MG。结果：GDM患者血清hs-CRP、Cys C和尿β2-MG水平分别为(2.96±1.38)mg/L、(1.35±0.42)mg/L和(1.75±0.49)mg/L，高于对照组（P<0.01）；而两组血清尿素、肌酐的差异无统计学意义(P>0.05)；GDM患者组的尿酸高于对照组（P<0.05）。结论：GDM患者血hs-CRP、Cys C和尿β2-MG水平的升高与GDM患者肾损伤的发生密切相关，联合检测可以提高GDM早期肾损伤诊断的准确性。
목적：탐토혈청초민C반응단백（hs-CRP）、광억소C（Cys C）화뇨β2-미구단백（β2-MG）연합검측재임신당뇨병（GDM）신병진단중적림상응용개치。방법：89례GDM환자화110례건강잉부위연구대상。재청신추취3ml공복정맥혈，경리심후득도혈청。동시수집24h뇨액。채용전자동생화분석의검측혈청뇨산、뇨소、기항、hs-CRP화Cys C；용면역비탁법검측뇨β2-MG。결과：GDM환자혈청hs-CRP、Cys C화뇨β2-MG수평분별위(2.96±1.38)mg/L、(1.35±0.42)mg/L화(1.75±0.49)mg/L，고우대조조（P<0.01）；이량조혈청뇨소、기항적차이무통계학의의(P>0.05)；GDM환자조적뇨산고우대조조（P<0.05）。결론：GDM환자혈hs-CRP、Cys C화뇨β2-MG수평적승고여GDM환자신손상적발생밀절상관，연합검측가이제고GDM조기신손상진단적준학성。
Objective:To investigate the clinical value of the combined examination of serum high-sensitive C-reactive protein (hs-CRP), cystatin C (Cys C), andβ2 urine microglobulin (β2-MG) for diagnosing renal damage of patients with gestational diabetes mellitus. Methods:Totally 89 gestational diabetes mellitus (GDM) patients and 110 healthy pregnant women in our hospital were analyzed. The serum hs-CRP, Cys C, urea, creatinine, uric acid and urineβ2-MG concentrations were measured in each group. Results:Serum hs-CRP, Cys C and urineβ2-MG of pa-tients of GDM group were obviously higher than those in the control group ( P<0.01), while the differences of serum urea, creatinine between the two groups showed no statistical significance ( P >0.05). Serum uric acid of GDM group was high er than this in the control group ( P<0.05). Conclusion:Cys C, hs-CRP, andβ2-MG are sensitive in-dicators for early diagnosing renal damage of patients with GDM. Combined examination can improve the accuracy of the early diagnosis of GDM.