CAJ | 학술논문

目的：研究鲍氏不动杆菌感染和TOLL样受体成员TLR‐5单核苷酸多态性之间相关性，为探讨鲍氏不动杆菌感染的早期预防提供理论依据。方法调查2010年1月－2012年11月402例鲍氏不动杆菌感染患者为试验组，385例非感染患者为对照组，对两组患者血液标本进行TLR‐5受体6个SNP位点检测，对各基因位点基因型频数、等位基因频数及单倍型分布情况进行比较和分析，采用SPSS10．0进行数据处理。结果 TLR‐5基因的两个SNPs（rs1341987和rs1640827），不符合哈迪‐温伯格平衡，其余4个SNPs位点符合哈迪‐温伯格平衡，多元logistic回归分析显示这些 SNPs多态性和单倍体型在病例组和对照组差异无统计学意义。结论 TLR‐5基因SNPs位点的多态性与中国人群中鲍氏不动杆菌感染无关。
목적：연구포씨불동간균감염화TOLL양수체성원TLR‐5단핵감산다태성지간상관성，위탐토포씨불동간균감염적조기예방제공이론의거。방법조사2010년1월－2012년11월402례포씨불동간균감염환자위시험조，385례비감염환자위대조조，대량조환자혈액표본진행TLR‐5수체6개SNP위점검측，대각기인위점기인형빈수、등위기인빈수급단배형분포정황진행비교화분석，채용SPSS10．0진행수거처리。결과 TLR‐5기인적량개SNPs（rs1341987화rs1640827），불부합합적‐온백격평형，기여4개SNPs위점부합합적‐온백격평형，다원logistic회귀분석현시저사 SNPs다태성화단배체형재병례조화대조조차이무통계학의의。결론 TLR‐5기인SNPs위점적다태성여중국인군중포씨불동간균감염무관。
OBJECTIVE To determine the association of the member of TOLL‐like receptors , TLR‐5 polymor‐phisms ,with Acinetobacter baumanii (Ab) infections ,so as to provide theoretical reference for early prevention of Ab infection .METHODS Totally 402 Ab infected patients during Jan .2010 to Nov .2012 were collected as the ex‐perimental group and 385 patients who collected from the same ward without infections were collected as the con‐trol group .The six SNP sites of TLR‐5 receptor detected in the blood samples ,the genotype frequency ,allele fre‐quency and haplotype distribution were compared and analyzed .The software SPSS10 .0 was used for data pro‐cessing .RESULTS Of the six SNPs of TLR‐5 gene ,four SNPs were in Hardy‐Weinbeg equilibrium and two (rs1341987 and rs1640827) were not .The multivariate logistic regression analysis showed that TLR‐5 SNP poly‐morphisms and haplotype showed no significant difference between infected patients and the control group . CONCLUSION The study suggests that TLR‐5 SNP polymorphism is not related to Ab infections in Chinese popu‐lation .