CAJ | 학술논문

背景：目前为止，椎间盘退变源性腰痛的发病机制研究并不十分清楚明了，对于其治疗的手段也多种多样，但效果不一。目的：综述近年国内外椎间盘退变机制及修复的研究进展。方法：由第一作者检索至2014年11月为止 PubMed数据(http：//www.ncbi.nlm.nih.gov/PubMed)及CNKI中国期刊全文数据库(http：//www.cnki.net/)，以“椎间盘退变因素，椎间盘源性腰痛，椎间盘退变治疗”等为检索词，共检索到78篇相关文献，排除重复研究，共30篇文献符合纳入标准。结果与结论：综合大量国内外科研人员对椎间盘退变的研究，目前比较推崇的退变因素包括形态学上的改变、炎性递质和细胞外基质的变化、生长因子的作用等，治疗上仍处于对其形态学的修复方面，其中经皮穿刺椎间盘减压、椎体融合、人工椎间盘置换、动态稳定系统等手术治疗方法对椎间盘退变引起的症状有确切的疗效。
배경：목전위지，추간반퇴변원성요통적발병궤제연구병불십분청초명료，대우기치료적수단야다충다양，단효과불일。목적：종술근년국내외추간반퇴변궤제급수복적연구진전。방법：유제일작자검색지2014년11월위지 PubMed수거(http：//www.ncbi.nlm.nih.gov/PubMed)급CNKI중국기간전문수거고(http：//www.cnki.net/)，이“추간반퇴변인소，추간반원성요통，추간반퇴변치료”등위검색사，공검색도78편상관문헌，배제중복연구，공30편문헌부합납입표준。결과여결론：종합대량국내외과연인원대추간반퇴변적연구，목전비교추숭적퇴변인소포괄형태학상적개변、염성체질화세포외기질적변화、생장인자적작용등，치료상잉처우대기형태학적수복방면，기중경피천자추간반감압、추체융합、인공추간반치환、동태은정계통등수술치료방법대추간반퇴변인기적증상유학절적료효。
BACKGROUND:So far, the pathogenesis of discogenic low back pain is poorly understood. A great diversity of therapeutic means is developed for discogenic low back pain, but the therapeutic outcomes are mixed. OBJECTIVE:To review the research progress in mechanisms and repair of intervertebral disc degeneration in recent years. METHODS: The first author retrieved the PubMed and CNKI databases for relevant articles published before November 2014 using the keywords of “disc degeneration factor, discogenic low back pain, disc degeneration therapy” in English and Chinese, respectively. Initialy, 78 relevant articles were retrieved, but only 30 articles were included in result analysis folowing elimination of duplicate studies. RESULTS AND CONCLUSION:The relatively respected factors for intervertebral disc degeneration include changes in morphology, inflammatory neurotransmitters and the extracelular matrix as wel as role of growth factors. The treatment for intervertebral disc degeneration stil focuses on the morphological restoration. Some surgical therapies, including percutaneous disc decompression, interbody fusion, artificial disc replacement, dynamic stabilization system, have the exact effects on the symptoms due to intervertebral disc degeneration.