CAJ | 학술논문

背景：骨的形成是一个动态的过程，破骨细胞和成骨细胞参与该动态过程。Semaphorin家族最早是作为轴突导向分子而被发现，其在许多不同组织里面表达并调节很多生理过程，近来更发现其在调节破骨细胞和成骨细胞方面发挥了重要作用。目的：总结Semaphorin家族各因子在骨动态平衡中发挥的作用。方法：应用计算机检索PubMed和Web of science数据库中1993年6月至2014年1月关于Semaphorin家族各因子调控骨代谢的文章，以“semaphorin，sema”为检索词进行检索；排除与研究内容无关和内容重复的文章，保留48篇文章进行综述。结果与结论：semaphorins在骨的细胞生物学方面是一类新型的调控分子，研究显示semaphorins通过一些特殊的机制很活跃的参与了骨的重塑过程，semaphorin家族蛋白在骨自身动态平衡中很关键，这些发现给治疗骨质疏松、骨硬化症、关节假体旁骨溶解等骨病提供了一种新颖的方法及治疗靶点。
배경：골적형성시일개동태적과정，파골세포화성골세포삼여해동태과정。Semaphorin가족최조시작위축돌도향분자이피발현，기재허다불동조직리면표체병조절흔다생리과정，근래경발현기재조절파골세포화성골세포방면발휘료중요작용。목적：총결Semaphorin가족각인자재골동태평형중발휘적작용。방법：응용계산궤검색PubMed화Web of science수거고중1993년6월지2014년1월관우Semaphorin가족각인자조공골대사적문장，이“semaphorin，sema”위검색사진행검색；배제여연구내용무관화내용중복적문장，보류48편문장진행종술。결과여결론：semaphorins재골적세포생물학방면시일류신형적조공분자，연구현시semaphorins통과일사특수적궤제흔활약적삼여료골적중소과정，semaphorin가족단백재골자신동태평형중흔관건，저사발현급치료골질소송、골경화증、관절가체방골용해등골병제공료일충신영적방법급치료파점。
BACKGROUND:Bone formation is a dynamic process, and osteoclasts and osteoblasts are involved in this dynamic process. Semaphorins were found first as axonal growth cone guidance molecules, which express in many different tissues and regulate many physiological processes. Recently, Semaphorins are confirmed to play an important role in the regulation of osteoclasts and osteoblasts. OBJECTIVE:To summarize the role of Semaphorins in bone homeostasis. METHODS: A computer-based search of PubMed and Web of Science was performed for articles related to the effect of Semaphorins in regulation of bone metabolism published from June 1993 to January 2014 using the keywords of “semaphorin, sema”. Irrelevant articles or duplicate content articles were excluded, and finaly 48 articles were reviewed. RESULTS AND CONCLUSION:Semaphorins act as a new class of regulatory molecules in the aspect of bone cytobiology. Studies have show semaphorins are actively involved in bone remodeling through some special mechanisms, and semaphorin proteins are crucial for bone homeostasis, which provides a new method and therapeutic target for the treatment of osteoporosis, bone sclerosis, osteolysis adjacent to joint prosthesis and other bone diseases.