CAJ | 학술논문

目的：研究前列腺素F2α受体(prostaglandin F2α receptor，PTGFR)在子宫腺肌病(adenomyosis，AM)患者子宫不同部位的表达与分布特征，探讨其与子宫腺肌病痛经的相关性。方法采用免疫组化SP法检测2013年10月-2014年6月就诊于我院的30例AM患者在位内膜组织及异位内膜组织PTGFR的表达，并和同期因子宫肌瘤行全子宫切除术且无痛经的30例患者正常子宫内膜组织作对照。通过视觉模拟评分法(visual analogue scale/score，VAS)对AM患者痛经程度进行评分，并分析其与PTGFR的相关性。结果 PTGFR在AM在位内膜、异位内膜和对照组的正常子宫内膜的阳性表达率及表达强度差异均有统计学意义(P＜0.05)；PTGFR在不同的月经周期表达差异无统计学意义(P＞0.05)；AM在位内膜组及异位内膜组痛经程度与PTGFR的表达强度之间均存在正相关，相关系数分别为0.7536(P＜0.01)和0.6193(P＜0.01)。结论 AM患者不同组织部位PTGFR的表达不同，痛经程度与在位内膜及异位内膜PTGFR的表达强度有关，PTGFR表达越强，痛经程度越严重。
목적：연구전렬선소F2α수체(prostaglandin F2α receptor，PTGFR)재자궁선기병(adenomyosis，AM)환자자궁불동부위적표체여분포특정，탐토기여자궁선기병통경적상관성。방법채용면역조화SP법검측2013년10월-2014년6월취진우아원적30례AM환자재위내막조직급이위내막조직PTGFR적표체，병화동기인자궁기류행전자궁절제술차무통경적30례환자정상자궁내막조직작대조。통과시각모의평분법(visual analogue scale/score，VAS)대AM환자통경정도진행평분，병분석기여PTGFR적상관성。결과 PTGFR재AM재위내막、이위내막화대조조적정상자궁내막적양성표체솔급표체강도차이균유통계학의의(P＜0.05)；PTGFR재불동적월경주기표체차이무통계학의의(P＞0.05)；AM재위내막조급이위내막조통경정도여PTGFR적표체강도지간균존재정상관，상관계수분별위0.7536(P＜0.01)화0.6193(P＜0.01)。결론 AM환자불동조직부위PTGFR적표체불동，통경정도여재위내막급이위내막PTGFR적표체강도유관，PTGFR표체월강，통경정도월엄중。
Objective To study the expression and distribution characteristics of the prostaglandin F2α receptors (PTGFR) in patients with adenomyosis, and discuss the association between uterine adenomyosis dysmenorrheal and PTGFR.Methods The expression of PTGFR was measured in the endometrium tissue and ectopic endometrium tissue of 30 AM patients admitted to our hospital from October 2013 to June 2014 with immunohistochemical method, and it was compared with the expression of PTGFR in normal endometrial tissue of 30 uterine-fibroid patients in the same period. Visual analogue scale/score was used to test the dysmenorrhea score in patients with AM and its correlation with PTGFR was analyzed.Results The difference of PTGFR among AM patients’ endometrium tissue, ectopic endometrium tissue and the normal endometrium of the control group had statistical significance in the positive expression rate and expression intensity (P<0.05); PTGFR expression in different menstrual cycle had no statistical significance (P>0.05); there was positive correlation between the degree of dysmenorrheal and the expressed intensity of PTGFR in the endometrium tissue group and ectopicendometrium group with the correlation coefficient of 0.753 6 (P<0.01) and 0.619 3 (P<0.01) respectively.ConclusionDifferent tissue of patients with AM have different PTGFR expression, degree of dysmenorrhea is related to expression intensity of PTGFR in the endometrium tissue group and ectopic endometrium group, the more expressed intensity of PTGFR shows in AM patients, the higher degree of dysmenorrheal is.