CAJ | 학술논문

钠钙交换蛋白是广泛存在于动物细胞膜上的一种离子转运蛋白，分为SLC8基因家族编码的钠钙交换蛋白(NCX)和SLC24基因家族编码的钾依赖的钠钙交换蛋白(NCKX)。新发现的线粒体NCLX由SLC8B1基因编码现被认为是NCX家族成员，对线粒体钙稳态起重要作用。NCX与心脑血管疾病、肿瘤、糖尿病关系密切；而NCKX参与光感、嗅觉、皮肤色素沉着、脑功能的调控。对钠钙交换蛋白的研究可为临床相关疾病的研究提供新思路。
납개교환단백시엄범존재우동물세포막상적일충리자전운단백，분위SLC8기인가족편마적납개교환단백(NCX)화SLC24기인가족편마적갑의뢰적납개교환단백(NCKX)。신발현적선립체NCLX유SLC8B1기인편마현피인위시NCX가족성원，대선립체개은태기중요작용。NCX여심뇌혈관질병、종류、당뇨병관계밀절；이NCKX삼여광감、후각、피부색소침착、뇌공능적조공。대납개교환단백적연구가위림상상관질병적연구제공신사로。
Sodium-calcium exchangers are widely expressed in animal cell membrane, which can be divided into two groups: the Na+/Ca2+ exchangers encoded by SLC8 gene family (NCX) and the K+ dependent Na+/Ca2+ exchangers encoded by SLC24 gene family (NCKX). A mitochondrial Na+/Ca2+ exchanger has recently been identified as NCLX protein, which is a gene product of SLC8B1, and it is now included in NCX family. NCLX plays an important role inmitochondrial calcium homeostasis. According to current studies, NCX is closely related with cardiovascular disease, cancer and diabetes; while NCKX participates in biological process like vision, olfaction, skin pigmentation and brain function. Researches focused on sodium-calcium exchanger can provide new ideas and new directions in clinic diseases.