CAJ | 학술논문

目的：观察红灵五黄汤治疗2型糖尿病（T2DM)的临床效果。方法：将180例患者随机分为治疗组和对照组各90例，治疗组给予红灵五黄汤治疗，对照组给予格列喹酮片和二甲双胍联合治疗，2组均以2个月为1个疗程，1个疗程后，观察症状、体征变化，检测空腹血糖(FBG）、餐后2小时血糖(2 hPG）、糖化血红蛋白(HbA1C）、肿瘤坏死因子α(TNF-α）、胰岛素抵抗(IR)、血酶及血脂的变化情况。结果：总有效率治疗组为88.8%，对照组为77.7%，治疗组优于对照组(P＜0.05)。FBG、2 hPG、HbA1C、TNF-α、IR、血酶及血脂等指标2组治疗后与治疗前相比差异有统计学意义(P＜0.05)。结论：红灵五黄汤治疗T2DM疗效显著，可能是通过健康胰岛B细胞，改善胰岛素抵抗，纠正血清酶的异常变化及降血糖、调血脂等过程而发挥作用的。
목적：관찰홍령오황탕치료2형당뇨병（T2DM)적림상효과。방법：장180례환자수궤분위치료조화대조조각90례，치료조급여홍령오황탕치료，대조조급여격렬규동편화이갑쌍고연합치료，2조균이2개월위1개료정，1개료정후，관찰증상、체정변화，검측공복혈당(FBG）、찬후2소시혈당(2 hPG）、당화혈홍단백(HbA1C）、종류배사인자α(TNF-α）、이도소저항(IR)、혈매급혈지적변화정황。결과：총유효솔치료조위88.8%，대조조위77.7%，치료조우우대조조(P＜0.05)。FBG、2 hPG、HbA1C、TNF-α、IR、혈매급혈지등지표2조치료후여치료전상비차이유통계학의의(P＜0.05)。결론：홍령오황탕치료T2DM료효현저，가능시통과건강이도B세포，개선이도소저항，규정혈청매적이상변화급강혈당、조혈지등과정이발휘작용적。
To observe clinical efficacy ofHongLingWuHuangTangin the treatment of type 2 dia-betes mellitus (T2DM). Methods: Totally180 patients with T2DM were randomly allocated to the treatment group and the control group, with 90 cases in each. HongLingWuHuang Tang was used in the treatment group. The combi-nation therapy of gliquidone tablets and metformin was carried out in the control group. Two months were one course of the treatment for both groups. After a course of treatment, the changes in symptoms and signs were ob-served, fasting blood glucose (FBG), 2 h postprandial glucose (2 hPG), glycosylated hemoglobin (HbA1C), tumor necrosis factor-α(TNF-α), insulin resistance (IR), blood enzymes and blood lipids detected. Results: Total effective rate in the treatment group was 88.8%, which was superior than 77.7% in the control group (P<0.05). The differ-ences in FBG, 2 hPG, HbA1C, TNF-α, IR, blood enzymes and blood lipids of two groups were statistically signifi-cant before and after the treatment (P<0.05). Conclusion: Clinical efficacy ofHongLingWuHuangTangis signifi-cant on T2DM. The possible mechanism rests on invigorating pancreatic B cells, improving IR, correcting abnormal serum enzymes, lowering blood glucose and transferring blood lipids.