中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
11期
1641-1646
,共6页
李远辉%杨运发%胡汉生%张光明%余升华%曾勉东%范震波
李遠輝%楊運髮%鬍漢生%張光明%餘升華%曾勉東%範震波
리원휘%양운발%호한생%장광명%여승화%증면동%범진파
组织构建%骨组织工程%腓骨移植%骨缺损%四肢%显微外科手术
組織構建%骨組織工程%腓骨移植%骨缺損%四肢%顯微外科手術
조직구건%골조직공정%비골이식%골결손%사지%현미외과수술
Fibula%Transplantation%Fractures,Bone%Extremities
背景:研究表明,带血管腓骨移植是修复四肢大段骨缺损的有效方法之一。目的:分析带血管腓骨移植修复四肢大段骨缺损的临床效果。方法:采用腓骨移植修复四肢大段骨缺损病例中选择非恶性肿瘤、随访20个月以上病例28例,清除病灶后应用带血管腓骨移植修复大段骨缺损,对于合并软组织缺损的病例同时用腓骨皮瓣或股前外侧皮瓣覆盖。结果与结论:所有病例随访20个月至6年,移植腓骨后3-8个月与受区骨达到骨愈合,术后10-22个月移植腓骨直径增粗致接近受区骨直径。Enneking系统评价肢体功能:胫骨大段骨缺损平均24.2分,肢体功能恢复81%,患者对手术满意程度达94%;股骨骨缺损平均26.3分,肢体功能恢复88%,患者对手术满意程度100%;桡尺骨远端骨缺损平均21.75分,肢体功能恢复72%,患者对手术满意程度100%。结果表明应用带血管腓骨移植修复四肢大段骨缺损可有效促进骨缺损愈合,降低致残、感染及截肢率,治疗后患者对肢体功能恢复满意。
揹景:研究錶明,帶血管腓骨移植是脩複四肢大段骨缺損的有效方法之一。目的:分析帶血管腓骨移植脩複四肢大段骨缺損的臨床效果。方法:採用腓骨移植脩複四肢大段骨缺損病例中選擇非噁性腫瘤、隨訪20箇月以上病例28例,清除病竈後應用帶血管腓骨移植脩複大段骨缺損,對于閤併軟組織缺損的病例同時用腓骨皮瓣或股前外側皮瓣覆蓋。結果與結論:所有病例隨訪20箇月至6年,移植腓骨後3-8箇月與受區骨達到骨愈閤,術後10-22箇月移植腓骨直徑增粗緻接近受區骨直徑。Enneking繫統評價肢體功能:脛骨大段骨缺損平均24.2分,肢體功能恢複81%,患者對手術滿意程度達94%;股骨骨缺損平均26.3分,肢體功能恢複88%,患者對手術滿意程度100%;橈呎骨遠耑骨缺損平均21.75分,肢體功能恢複72%,患者對手術滿意程度100%。結果錶明應用帶血管腓骨移植脩複四肢大段骨缺損可有效促進骨缺損愈閤,降低緻殘、感染及截肢率,治療後患者對肢體功能恢複滿意。
배경:연구표명,대혈관비골이식시수복사지대단골결손적유효방법지일。목적:분석대혈관비골이식수복사지대단골결손적림상효과。방법:채용비골이식수복사지대단골결손병례중선택비악성종류、수방20개월이상병례28례,청제병조후응용대혈관비골이식수복대단골결손,대우합병연조직결손적병례동시용비골피판혹고전외측피판복개。결과여결론:소유병례수방20개월지6년,이식비골후3-8개월여수구골체도골유합,술후10-22개월이식비골직경증조치접근수구골직경。Enneking계통평개지체공능:경골대단골결손평균24.2분,지체공능회복81%,환자대수술만의정도체94%;고골골결손평균26.3분,지체공능회복88%,환자대수술만의정도100%;뇨척골원단골결손평균21.75분,지체공능회복72%,환자대수술만의정도100%。결과표명응용대혈관비골이식수복사지대단골결손가유효촉진골결손유합,강저치잔、감염급절지솔,치료후환자대지체공능회복만의。
BACKGROUND:Vascularuzed fibular graft is one of the effective methods for repair of large segmental bone defects in the extremities OBJECTIVE:To explore the clinical effects of vascularized fibular graft for repairing large segmental bone defects in the extremities. METHODS:Twenty-eight non-malignant patients who received vascularized fibular graft for repairing large segmental bone defects in the extremities and were folowed up for more than 20 months were enroled. After lesion removal, vascularized fibula bone graft was used to repair the bone defects. If cases combined with soft tissue defects, fibula flap or anterolateral thigh flap was adopted. RESULTS AND CONCLUSION: Al patients were folowed up for 20 months to 6 years. The grafted bones were healed with the surrounding bone at 3-8 months after fibula bone grafting. The grafted bone was enlarged near to the diameter of recipient bone at 10-22 months after grafting. Based on the Enneking system, the average score of large segmental tibia bone defects was 24.2 points with 81% limb function recovered and 94.1% patient satisfaction; the average score of large segmental femur bone defects was 26.3 points with 87.7% limb function recovered and 100% patient satisfaction; the average score of large segmental bone defects of the distal radius and ulna was 21.75 points with 72.5% limb function recovered and 100% patient satisfaction. These findings reveal that vascularized fibular graft for repairing large segmental bone defects in extremities can effectively promote bone healing and reduce disability, infection, amputation rate; moreover, patients are satisfied with the postoperative recovery of limb function.