CAJ | 학술논문

目的：研究胃癌变过程中凋亡基因生存素（Survivin）和 Bcl‐2基因表达与幽门螺杆菌（Hp）感染的相关性，为临床治疗提供参考依据。方法选取医院2008年1月－2009年12月140例胃病患者送检胃黏膜组织标本，检测凋亡基因Survivin、Bcl‐2的表达以及Hp的感染情况，并就其相关性进行分析，采用SPSS 19．0软件进行统计分析。结果 Hp阳性率在不同疾病胃黏膜组织中存在差异，在病变恶性程度最高的胃癌中，Hp的阳性率最高，为69．70％；胃黏膜肠上皮生化生、胃黏膜不典型增生及胃癌与慢性浅表性胃炎H p的阳性率差异有统计学意义（P＜0．05），胃癌患者Survivin、Bcl‐2阳性表达率均较高，分别为63．64％、60．61％，随胃癌变发展过程呈逐渐增加趋势；相关性分析表明，Hp感染、Survivin、Bcl‐2表达与胃癌变恶化程度差异有统计学意义（P＜0．05）；细胞凋亡指数（AI）在胃癌变发展过程中先升高后下降。结论凋亡基因 Bcl‐2和Survivin在胃癌变过程中有表达逐渐升高趋势，Hp感染能够诱导Survivin、Bcl‐2基因表达，导致细胞凋亡受抑制。
목적：연구위암변과정중조망기인생존소（Survivin）화 Bcl‐2기인표체여유문라간균（Hp）감염적상관성，위림상치료제공삼고의거。방법선취의원2008년1월－2009년12월140례위병환자송검위점막조직표본，검측조망기인Survivin、Bcl‐2적표체이급Hp적감염정황，병취기상관성진행분석，채용SPSS 19．0연건진행통계분석。결과 Hp양성솔재불동질병위점막조직중존재차이，재병변악성정도최고적위암중，Hp적양성솔최고，위69．70％；위점막장상피생화생、위점막불전형증생급위암여만성천표성위염H p적양성솔차이유통계학의의（P＜0．05），위암환자Survivin、Bcl‐2양성표체솔균교고，분별위63．64％、60．61％，수위암변발전과정정축점증가추세；상관성분석표명，Hp감염、Survivin、Bcl‐2표체여위암변악화정도차이유통계학의의（P＜0．05）；세포조망지수（AI）재위암변발전과정중선승고후하강。결론조망기인 Bcl‐2화Survivin재위암변과정중유표체축점승고추세，Hp감염능구유도Survivin、Bcl‐2기인표체，도치세포조망수억제。
OBJECTIVE To study the expression of survivin and Bcl‐2 during the course of gastric canceration and explore the relationship between survivin ,Bcl‐2 and Hp infection ,so as to provide clinical references .METHODS The gastric mucosa samples of 140 patients who were admitted from Jan .2008 to Dec .2009 with stomach illness were examined .The expression of survivin and Bcl‐2 and the rate of HP infections were detected .Relevance anal‐ysis were conducted by SPSS 19 .0 software .RESULTS The Hp positive rates differed in distinct gastric illness . The Hp positive rate was the highest in stomach cancer with highest grade malignancy ,with the rate of 69 .70% . The differences between Hp positive rates of intestinal metaplasia ,gastric mucosal dysplasia ,stomach cancer and chronic superficial gastritis were significant (P< 0 .05) .The survivin and Bcl‐2 positive expression rates were high in patients with gastric cancer ,with the rate of 63 .64% and 60 .61% respectively .Relevance analysis showed that the HP infection and the expression of survivin ,Bcl‐2 had a significantly positive correlation with the degree of canceration .The difference was significant (P<0 .05) .And AI showed a downward trend after the first rise in the developing course of stomach canceration .CONCLUSION The expression of survivin and Bcl‐2 increased with the developing process of gastric cancer .The HP infection will induce the expression of survivin and Bcl‐2 that can control the apoptosis .