心血管康复医学杂志
心血管康複醫學雜誌
심혈관강복의학잡지
JOURNAL OF CARDIOVASCULAR REHABILITATION MEDICINE
2015年
2期
139-142
,共4页
肥胖,腹部%高血压%危险因素
肥胖,腹部%高血壓%危險因素
비반,복부%고혈압%위험인소
Obesity,abdominal%Hypertension%central obesity%Risk factors
目的:探讨血清网膜素-1在中心肥胖(CO)伴原发高血压(EH)患者的表达及其意义。方法:采用酶联免疫吸附试验检测57例无原发高血压病中心肥胖者(单纯CO组)和67例CO伴EH患者(CO+ EH组)血清网膜素-1水平,并选56名正常健康者作为正常对照组。对各组血糖、血脂生化指标进行比较分析,并利用Logistic多元逐步回归进行危险因素分析。结果:CO + EH 组血清网膜素-1水平明显低于单纯 CO 组和正常对照组[(25.15±3.95) ng/ml比(45.63±9.66) ng/ml、(53.12±7.97) ng/ml , P<0.05或<0.01],单纯CO组与正常对照组间血清网膜素-1水平无统计学差异(P>0.05);Logistic多元逐步回归分析表明年龄和稳态模型胰岛素抵抗指数(HOM A -IR)是影响肥胖人群高血压发生的独立危险因素(OR=1.124,95% CI:1.000-1.248, P=0.049;OR=3.446,95% CI:1.087-5.607, P=0.001),而血清网膜素-1水平是独立保护因素(OR=0.423,95% CI:0.210-0.636, P=0.001)。结论:血清网膜素-1水平对中心性肥胖伴原发高血压的早期诊断和防治可能具有一定的指导意义。
目的:探討血清網膜素-1在中心肥胖(CO)伴原髮高血壓(EH)患者的錶達及其意義。方法:採用酶聯免疫吸附試驗檢測57例無原髮高血壓病中心肥胖者(單純CO組)和67例CO伴EH患者(CO+ EH組)血清網膜素-1水平,併選56名正常健康者作為正常對照組。對各組血糖、血脂生化指標進行比較分析,併利用Logistic多元逐步迴歸進行危險因素分析。結果:CO + EH 組血清網膜素-1水平明顯低于單純 CO 組和正常對照組[(25.15±3.95) ng/ml比(45.63±9.66) ng/ml、(53.12±7.97) ng/ml , P<0.05或<0.01],單純CO組與正常對照組間血清網膜素-1水平無統計學差異(P>0.05);Logistic多元逐步迴歸分析錶明年齡和穩態模型胰島素牴抗指數(HOM A -IR)是影響肥胖人群高血壓髮生的獨立危險因素(OR=1.124,95% CI:1.000-1.248, P=0.049;OR=3.446,95% CI:1.087-5.607, P=0.001),而血清網膜素-1水平是獨立保護因素(OR=0.423,95% CI:0.210-0.636, P=0.001)。結論:血清網膜素-1水平對中心性肥胖伴原髮高血壓的早期診斷和防治可能具有一定的指導意義。
목적:탐토혈청망막소-1재중심비반(CO)반원발고혈압(EH)환자적표체급기의의。방법:채용매련면역흡부시험검측57례무원발고혈압병중심비반자(단순CO조)화67례CO반EH환자(CO+ EH조)혈청망막소-1수평,병선56명정상건강자작위정상대조조。대각조혈당、혈지생화지표진행비교분석,병이용Logistic다원축보회귀진행위험인소분석。결과:CO + EH 조혈청망막소-1수평명현저우단순 CO 조화정상대조조[(25.15±3.95) ng/ml비(45.63±9.66) ng/ml、(53.12±7.97) ng/ml , P<0.05혹<0.01],단순CO조여정상대조조간혈청망막소-1수평무통계학차이(P>0.05);Logistic다원축보회귀분석표명년령화은태모형이도소저항지수(HOM A -IR)시영향비반인군고혈압발생적독립위험인소(OR=1.124,95% CI:1.000-1.248, P=0.049;OR=3.446,95% CI:1.087-5.607, P=0.001),이혈청망막소-1수평시독립보호인소(OR=0.423,95% CI:0.210-0.636, P=0.001)。결론:혈청망막소-1수평대중심성비반반원발고혈압적조기진단화방치가능구유일정적지도의의。
Objective:To explore expression of plasma omentin -1 in patients with central obesity (CO) complicated essential hypertension (EH) and its clinical significance .Methods : Serum level of omentin - 1 was measured by enzyme linked immunosorbent assay in 57 CO patients without EH (pure CO group) and 67 CO complicated EH patients (CO + EH group) ,and 56 healthy subjects (normal control group) .Blood glucose ,blood lipid and biochemical indexes were compared and analyzed among three groups ,and Logistic multi - factor gradual regression analysis was used to perform risk factor analysis .Results : Serum omentin - 1 level in CO + EH group was significantly lower than those of pure CO group and normal control group [ (25.15 ± 3.95) ng/ml vs .(45.63 ± 9.66) ng/ml ,(53.12 ± 7.97) ng/ml , P < 0.05 or < 0.01] ,but there was no significant difference between pure CO and normal control group , P > 0.05 ;Logistic multi - factor gradual regression analysis indicated that age and homeostasis model - insulin resistance index (HOMA - IR ) were independent risk factors affecting EH occurrence in obese people (OR = 1.124 ,95% CI : 1.000 - 1.248 ,P = 0.049 ;OR = 3.446 ,95% CI : 1.087 - 5.607 ,P = 0.001) ,while serum omentin - 1 level was an independent protective factor (OR = 0.423 ,95% CI : 0.210 - 0.636 , P = 0.001) .Conclusion : Serum omentin - 1 level may possess certain guiding significance in early diagnosis ,prevention and treatment for patients with central obesity complicated essential hypertension .