CAJ | 학술논문

目的：探讨血压晨峰、动态动脉硬化指数（AASI）与颈动脉内膜中层厚度（IM T ）的相关性。方法：对212例入选高血压病例监测24h动态血压，并行颈动脉超声检查，测量颈总动脉IM T ，根据IM T增厚与否分为IM T正常组（84例）和IM T增厚组（128例），计算血压晨峰值及AASI；根据是否存在血压晨峰现象，分为血压晨峰组（120例）和无血压晨峰组（92例），观察血压晨峰、AASI与颈动脉 IM T 的相关性。结果：与IM T 正常组比较， IMT增厚组中AASI [（0.42±0.13）比（0.68±0.14）]及血压晨峰值[（25.94±4.57） mmHg比（36.57±8.41） mmHg]明显升高（P＜0.05）；与无血压晨峰组比较，血压晨峰组中 AASI [（0.43±0.13）比（0.71±0.14）]、IMT [（1.01±0.20） mm比（1.25±0.17） mm]显著增加（P＜0.05）；直线相关分析结果显示，血压晨峰、AA‐SI与颈动脉IMT呈正相关（r＝1.22，0.51， P均＜0.05）。结论：血压晨峰和动态动脉硬化指数是颈动脉内膜中层厚度的独立危险因素，且具有预测价值。
목적：탐토혈압신봉、동태동맥경화지수（AASI）여경동맥내막중층후도（IM T ）적상관성。방법：대212례입선고혈압병례감측24h동태혈압，병행경동맥초성검사，측량경총동맥IM T ，근거IM T증후여부분위IM T정상조（84례）화IM T증후조（128례），계산혈압신봉치급AASI；근거시부존재혈압신봉현상，분위혈압신봉조（120례）화무혈압신봉조（92례），관찰혈압신봉、AASI여경동맥 IM T 적상관성。결과：여IM T 정상조비교， IMT증후조중AASI [（0.42±0.13）비（0.68±0.14）]급혈압신봉치[（25.94±4.57） mmHg비（36.57±8.41） mmHg]명현승고（P＜0.05）；여무혈압신봉조비교，혈압신봉조중 AASI [（0.43±0.13）비（0.71±0.14）]、IMT [（1.01±0.20） mm비（1.25±0.17） mm]현저증가（P＜0.05）；직선상관분석결과현시，혈압신봉、AA‐SI여경동맥IMT정정상관（r＝1.22，0.51， P균＜0.05）。결론：혈압신봉화동태동맥경화지수시경동맥내막중층후도적독립위험인소，차구유예측개치。
Objective:To explore the correlation among morning blood pressure surge (MBPS) ,ambulatory arterial stiffness index (AASI) and carotid artery intima‐media thickness (IMT) .Methods :A total of 212 hypertension pa‐tients received 24h ambulatory blood pressure monitoring and carotid artery ultrasonography to measure carotid IMT .According to IMT thickened or not ,they were divided into normal IMT group (n=84) and thickened IMT group (n = 128) ,then MBPS and AASI were calculated .According to MBPS existed or not ,patients were divided into MBPS group (n = 120) and no MBPS group (n = 92) ,then the correlation among MBPS ,AASI and carotid IMT were observed .Results : Compared with normal IMT group ,there were significant rise in AASI [ (0.42 ± 0.13) vs .(0.68 ± 0.14)] and MBPS value [ (25.94 ± 4.57) mmHg vs .(36.57 ± 8.41) mmHg] in thickened IMT group , P < 0.05 both ;compared with no MBPS group ,there were significant rise in AASI [ (0.43 ± 0.13) vs .(0.71 ± 0.14)] and IMT [(1.01 ± 0.20) mm vs .(1.25 ± 0.17) mm] in MBPS group ,P < 0.05 both ;Linear correlation analysis indicated that MBPS and AASI were positively correlated with carotid IMT ( r = 1.22 ,0.51 , P < 0.05 both) .Conclusion : Morning blood pressure surge and ambulatory arterial stiffness index are independent risk factors for carotid artery intima‐media thickness ,and they possess predictive value .